西班牙巴伦西亚人类非A组轮状病毒感染的血清流行病学

Seroepidemiology of Human Non-Species A Rotavirus Infections in Valencia, Spain.

作者信息

Navarro-Lleó Noemi, Aznar-Córdoba Silvia, Asensio-Cob Dunia, Luque Daniel, Rodríguez Javier M, Gozalbo-Rovira Roberto, Alcaraz-Soriano María Jesús, Cárcamo-Calvo Roberto, Rodríguez-Díaz Jesús, Buesa Javier

机构信息

Faculty of Medicine, University of Valencia, Valencia, Spain.

Instituto de Salud Carlos III, Centro Nacional de Microbiología, Majadahonda, Spain.

出版信息

J Med Virol. 2025 Aug;97(8):e70542. doi: 10.1002/jmv.70542.

DOI:10.1002/jmv.70542

PMID:40751697

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12317683/

Abstract

Species A rotavirus (RVA) is a major cause of acute gastroenteritis in children. However, three other rotavirus species (RVB, RVC, and RVH) are also able to infect humans. It has been suggested that vaccination against RVA could facilitate an increase of non-A rotavirus infections. We investigated the antibody prevalence against RVA, RVB, RVC, and RVH in 420 human sera collected between 2020 and 2022 from different age groups in Valencia (Spain). Antibody prevalence rates to RVA, RVB, RVC, and RVH were 79.3%, 17.9%, 18.8%, and 14.5%, respectively. Antibody titers against RVA remained consistent across the different age groups, and RVB showed low titers except in younger individuals. RVC-specific antibodies peaked in children 5-10 years of age, whereas RVH exhibited the highest titers in the elderly. The detection of antibodies against non-A rotaviruses in humans in Spain, for the first time against RVB and RVH, highlights the need for their surveillance.

摘要

A组轮状病毒（RVA）是儿童急性胃肠炎的主要病因。然而，其他三种轮状病毒（RVB、RVC和RVH）也能够感染人类。有人提出，接种RVA疫苗可能会促使非A组轮状病毒感染增加。我们调查了2020年至2022年间从西班牙巴伦西亚不同年龄组收集的420份人类血清中针对RVA、RVB、RVC和RVH的抗体流行情况。RVA、RVB、RVC和RVH的抗体流行率分别为79.3%、17.9%、18.8%和14.5%。不同年龄组针对RVA的抗体滴度保持一致，除了较年轻个体外，RVB的抗体滴度较低。RVC特异性抗体在5至10岁儿童中达到峰值，而RVH在老年人中抗体滴度最高。在西班牙首次检测到人类针对非A组轮状病毒（针对RVB和RVH）的抗体，这凸显了对其进行监测的必要性。