Estarriaga-Navarro Silvia, Goicoechea Nieves, Plano Daniel, Sanmartín Carmen
School of Pharmacy and Nutrition, Department of Pharmaceutical Sciences, University of Navarra, Pamplona, Spain.
BIOMA (Institute for Biodiversity and the Environment), Plant Stress Physiology Group, University of Navarra, Pamplona, Spain.
J Sci Food Agric. 2025 Aug 2. doi: 10.1002/jsfa.70103.
Selenium (Se) biofortification in crops has emerged as a promising strategy to address global Se deficiencies and enhance both agricultural productivity and human health. Increasing the Se content of crops through biofortification improves their resilience to abiotic and biotic stresses and boosts their nutritional value. This benefits human health by protecting against diseases such as cancer, infections and allergies when the crops are consumed. Furthermore, Se-biofortified non-edible plant parts have significant potential in biomedicine and could enhance the value of agricultural byproducts. This strategy contributes to a circular economy by reducing waste, improving resource efficiency and providing sustainable alternatives to synthetic pharmaceuticals and supplements. Ultimately, it supports environmental and economic sustainability. Nevertheless, Se biofortification faces several challenges, particularly with regard to standardization, acceptance by consumers and farmers, and the regulatory and economic frameworks that govern its implementation. Effectively addressing these issues is crucial to unlocking the full potential of Se biofortification. This could significantly improve global nutritional outcomes, reduce the prevalence of Se deficiency-related health conditions, support the prevention and treatment of diseases and promote sustainable agricultural practices that align with long-term food security goals. In this context, future perspectives highlight the promising integration of biofortified residues generated by Se biofortification with emerging technologies such as biorefineries and artificial intelligence. These residues could be efficiently valorized and repurposed through biorefinery processes optimized by artificial intelligence, contributing to a circular economy and sustainable resource management. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
作物中的硒（Se）生物强化已成为一种有前景的策略，可解决全球硒缺乏问题，并提高农业生产力和人类健康水平。通过生物强化提高作物的硒含量，可增强其对非生物和生物胁迫的抵御能力，并提升其营养价值。当食用这些作物时，这对人类健康有益，可预防癌症、感染和过敏等疾病。此外，硒生物强化的非食用植物部分在生物医学领域具有巨大潜力，还可提高农业副产品的价值。该策略通过减少浪费、提高资源效率以及为合成药物和补充剂提供可持续替代品，促进了循环经济。最终，它支持环境和经济的可持续性。然而，硒生物强化面临若干挑战，特别是在标准化、消费者和农民的接受度以及管理其实施的监管和经济框架方面。有效解决这些问题对于释放硒生物强化的全部潜力至关重要。这可显著改善全球营养状况，降低与硒缺乏相关健康状况的发生率，支持疾病的预防和治疗，并促进与长期粮食安全目标相一致的可持续农业实践。在此背景下，未来展望突出了硒生物强化产生的生物强化残留物与生物精炼厂和人工智能等新兴技术的有前景整合。这些残留物可通过人工智能优化的生物精炼过程高效增值和重新利用，为循环经济和可持续资源管理做出贡献。© 2025作者。《食品与农业科学杂志》由约翰·威利父子有限公司代表化学工业协会出版。
