Zhu Boyu, Zhu Lihang, Wang Hao, Li Xinru, Zhao Ziyi, Zhou Lin, Gao Zhigang, Hu Ning, Su Bin
Zhejiang Key Laboratory of Excited-State Energy Conversion and Energy Storage, State Key Laboratory of Soil Pollution Control and Safety, Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China.
Department of Clinical Engineering, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310009, China.
Biosens Bioelectron. 2025 Nov 15;288:117840. doi: 10.1016/j.bios.2025.117840. Epub 2025 Jul 29.
Continuous monitoring of physicochemical information during exercise using wearable and implantable systems is critical for disease management and health monitoring. However, it remains challenging due to limited multimodal system integration, poor detection precision, and rigidity of the equipment. Herein, we present a fully printed multimodal sensing system (MSS) that integrates an implantable glucose/lactate biosensor, wearable electrocardiogram (ECG) and temperature sensors with the reusable electronics. This flexible system fabricated completely by the screen-printing technology enables the wireless real-time monitoring of interstitial fluid biochemical parameters and vital signs during exercise. The experimental validation in anesthetized rats shows that the MSS has a high measurement consistency with Pearson correlation coefficients exceeding 0.96 compared to separated commercial instruments. The MSS successfully realizes the multimodal real-time health monitoring during exercise and accurately reports the physiological effects of exercise in diabetic model rats, such as glucose decline, lactate accumulation, increased heart rate and elevated skin temperature. In addition, it is found that regular exercise can reduce the increase in lactate and heart rate levels, confirming that exercise indeed improves the athletic performance. This novel method provides a robust platform for dynamic real-time monitoring of exercise metabolism, holding a great promise in accurate exercise and health management.
使用可穿戴和植入式系统在运动期间持续监测物理化学信息对于疾病管理和健康监测至关重要。然而，由于多模态系统集成有限、检测精度差以及设备的刚性，这仍然具有挑战性。在此，我们展示了一种全印刷多模态传感系统（MSS），该系统将植入式葡萄糖/乳酸生物传感器、可穿戴心电图（ECG）和温度传感器与可重复使用的电子设备集成在一起。这种完全通过丝网印刷技术制造的柔性系统能够在运动期间对组织间液生化参数和生命体征进行无线实时监测。在麻醉大鼠中的实验验证表明，与单独的商用仪器相比，MSS具有高测量一致性，皮尔逊相关系数超过0.96。MSS成功实现了运动期间的多模态实时健康监测，并准确报告了糖尿病模型大鼠运动的生理效应，如血糖下降、乳酸积累、心率增加和皮肤温度升高。此外，发现定期运动可以减少乳酸和心率水平的升高，证实运动确实提高了运动表现。这种新方法为运动代谢的动态实时监测提供了一个强大的平台，在精确的运动和健康管理方面具有巨大潜力。
