Kuttan R, Bhanumathy P, Nirmala K, George M C
Cancer Lett. 1985 Nov;29(2):197-202. doi: 10.1016/0304-3835(85)90159-4.
Anticancer activity of the rhizomes of turmeric was evaluated in vitro using tissue culture methods and in vivo in mice using Dalton's lymphoma cells grown as ascites form. Turmeric extract inhibited the cell growth in Chinese Hamster Ovary (CHO) cells at a concentration of 0.4 mg/ml and was cytotoxic to lymphocytes and Dalton's lymphoma cells at the same concentration. Cytotoxic effect was found within 30 min at room temperature (30 degrees C). The active constituent was found to be 'curcumin' which showed cytotoxicity to lymphocytes and Dalton's lymphoma cells at a concentration of 4 micrograms/ml. Initial experiments indicated that turmeric extract and curcumin reduced the development of animal tumours.
采用组织培养方法在体外评估了姜黄根茎的抗癌活性，并在体内使用以腹水形式生长的道尔顿淋巴瘤细胞对小鼠进行了评估。姜黄提取物在浓度为0.4mg/ml时抑制中国仓鼠卵巢（CHO）细胞的生长，并且在相同浓度下对淋巴细胞和道尔顿淋巴瘤细胞具有细胞毒性。在室温（30摄氏度）下30分钟内发现了细胞毒性作用。发现活性成分是“姜黄素”，其在浓度为4微克/毫升时对淋巴细胞和道尔顿淋巴瘤细胞表现出细胞毒性。初步实验表明，姜黄提取物和姜黄素减少了动物肿瘤的发生。
