DeGregorio M W, King O Y, Holleran W M, Wilbur B J, Cadman E C, Deisseroth A B, Wilbur J R
Cancer Treat Rep. 1985 Dec;69(12):1441-2.
Ultrafiltrate and total plasma and cerebrospinal fluid (CSF) platinum concentrations were examined in a patient with neuroblastoma following a 2-hour infusion of 120 mg/m2 of cisplatin. Total plasma platinum was 93.4% bound, while the ultrafiltrate of plasma accounted for the remaining 6.6%. The CSF ultrafiltrate resulted in equivalent concentrations of platinum to total CSF platinum. CSF concentrations were 2.9% of the total plasma platinum and 43.5% of the ultrafiltrate plasma platinum 2 hours after the end of the infusion.
在一名神经母细胞瘤患者静脉输注120mg/m²顺铂2小时后，检测了其超滤液、全血浆及脑脊液（CSF）中的铂浓度。血浆中93.4%的铂呈结合状态，而血浆超滤液中的铂占其余的6.6%。脑脊液超滤液中的铂浓度与脑脊液总铂浓度相当。输注结束2小时后，脑脊液中的铂浓度为血浆总铂浓度的2.9%，为血浆超滤液铂浓度的43.5%。
