老年非透析慢性肾脏病患者中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、红细胞分布宽度与身体功能之间的关联

The association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, red blood cell distribution width, and physical function in elderly non-dialysis patients with chronic kidney disease.

作者信息

Chang Jing, Qi Zhuoran, Yin Xiukun, Fang Xiangyang, Sun Qianmei

机构信息

Department of Internal Medicine, Beijing Chao-yang Hospital, Capital Medical University, Beijing, 100020, China.

Department of Nephrology, Civil Aviation General Hospital, Beijing, 100020, China.

出版信息

BMC Geriatr. 2025 Aug 2;25(1):580. doi: 10.1186/s12877-025-06277-x.

DOI:10.1186/s12877-025-06277-x

PMID:40753189

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12318392/

Abstract

BACKGROUND

The physical function of elderly patients with chronic kidney disease (CKD) is influenced by chronic inflammatory status. This study aimed to investigate the association between systemic inflammatory markers—neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW)—and physical function in elderly non-dialysis patients with CKD.

METHODS

Data were collected from CKD patients aged ≥ 60 years. Physical function was evaluated using the Barthel Index (BI) of the activities of daily living (ADL) scale. Participants were stratified into two groups: BI ≥ 60 and BI < 60. Differences in NLR, PLR, and RDW levels between the two groups were compared. Subsequently, multivariable logistic regression analysis was performed to assess the association of these three indicators (as continuous or categorical variables) with physical function.

RESULTS

A total of 1005 eligible patients were included, comprising 880 patients in the BI ≥ 60 group and 125 patients in the BI < 60 group. NLR (3.71 ± 1.78 vs. 2.82 ± 1.58, < 0.001), PLR (158.50 ± 66.98 vs. 138.84 ± 63.48, = 0.001), and RDW (14.01 ± 1.47 vs. 13.38 ± 1.30, < 0.001) were significantly higher in the BI < 60 group compared to the BI ≥ 60 group. Multivariable regression analysis demonstrated that elevated NLR (OR = 1.278, 95% CI: 1.138–1.435, < 0.001) and PLR (OR = 1.004, 95% CI: 1.001–1.006, = 0.014) were independently associated with physical function dependence in elderly non-dialysis CKD patients.

CONCLUSION

Higher levels of NLR, PLR, and RDW were observed in elderly non-dialysis CKD patients with poor physical function. Elevated NLR and PLR were independently associated with physical function dependence.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1186/s12877-025-06277-x.

摘要

背景

慢性肾脏病（CKD）老年患者的身体功能受慢性炎症状态影响。本研究旨在探讨全身炎症标志物——中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）及红细胞分布宽度（RDW）——与老年非透析CKD患者身体功能之间的关联。

方法

收集年龄≥60岁的CKD患者的数据。使用日常生活活动能力（ADL）量表的巴氏指数（BI）评估身体功能。参与者被分为两组：BI≥60和BI<60。比较两组间NLR、PLR和RDW水平的差异。随后，进行多变量逻辑回归分析，以评估这三个指标（作为连续或分类变量）与身体功能的关联。

结果

共纳入1005例符合条件的患者，其中BI≥60组880例，BI<60组125例。与BI≥60组相比，BI<60组的NLR（3.71±1.78 vs. 2.82±1.58，<0.001）、PLR（158.50±66.98 vs. 138.84±63.48，=0.001）和RDW（14.01±1.47 vs. 13.38±1.30，<0.001）显著更高。多变量回归分析表明，NLR升高（OR=1.278，95%CI：1.138–1.435，<0.001）和PLR升高（OR=1.004，95%CI：1.001–1.006，=0.014）与老年非透析CKD患者的身体功能依赖独立相关。