Chemerinski Anat, Blackledge Kristin, Greenberg Patricia, Douglas Nataki C, McGovern Peter G, Morelli Sara S
Rutgers Biomedical and Health Sciences, 185 S Orange Ave, Newark, NJ, 07103, USA.
School of Public Health Rutgers Biomedical and Health Sciences, 683 Hoes Ln W, Piscataway, NJ, 08854, USA.
Reprod Biol Endocrinol. 2025 Aug 2;23(1):115. doi: 10.1186/s12958-025-01451-7.
Age is known to affect the success of assisted reproductive technology (ART) treatment. While significant research efforts have been directed at investigating the effects of aging on oocytes, few studies have examined the effect of aging on the endometrium. We sought to assess whether age negatively impacts peak endometrial thickness achieved in frozen embryo transfer (FET) cycles.
This was a retrospective cohort study utilizing the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) database between 2016 and 2020. Young (< 35) and older (≥35yo) non-identified oocyte donor (NOD) recipients were included to assess the impact of age on endometrial thickness; young and older gestational carriers (GCs) served as the respective controls for these two groups. The primary outcome was peak endometrial thickness achieved in an FET cycle; additional outcomes included cycle cancellation rate, clinical pregnancy rate and live birth rate.
We observed a weak association between age and endometrial thickness in both NOD recipient and GC cycles. Though pregnancy rates were slightly lower at endometrial thicknesses < 8 mm, we observed no difference in clinical pregnancy rate with endometrial thicknesses between 8 and 18 mm. We found a significantly higher clinical pregnancy rate in GCs compared to NOD recipients in both the young and older age groups, and noted a decreasing clinical pregnancy rate with age in all groups.
Our data suggest an age-related decline in pregnancy rates in donor oocyte recipients and gestational carrier cycles, in which an endometrial factor would not necessarily be anticipated; this endometrial factor does not appear to be related to endometrial thickness. Therefore, our data support the existence of an endometrial factor that cannot be assessed by measurements of thickness, but nevertheless plays a crucial role in the success of an embryo implantation.
Not applicable.
已知年龄会影响辅助生殖技术（ART）治疗的成功率。虽然已有大量研究致力于调查衰老对卵母细胞的影响，但很少有研究探讨衰老对子宫内膜的影响。我们试图评估年龄是否会对冷冻胚胎移植（FET）周期中达到的子宫内膜峰值厚度产生负面影响。
这是一项回顾性队列研究，利用2016年至2020年辅助生殖技术协会诊所结局报告系统（SART CORS）数据库。纳入年轻（<35岁）和年长（≥35岁）的未识别卵母细胞捐赠者（NOD）受者，以评估年龄对子宫内膜厚度的影响；年轻和年长的妊娠载体（GC）分别作为这两组的对照。主要结局是FET周期中达到的子宫内膜峰值厚度；其他结局包括周期取消率、临床妊娠率和活产率。
我们在NOD受者和GC周期中均观察到年龄与子宫内膜厚度之间存在微弱关联。尽管子宫内膜厚度<8mm时妊娠率略低，但我们观察到子宫内膜厚度在8至18mm之间时临床妊娠率没有差异。我们发现，在年轻和年长年龄组中，GC的临床妊娠率均显著高于NOD受者，并注意到所有组的临床妊娠率均随年龄下降。
我们的数据表明，在捐赠卵母细胞受者和妊娠载体周期中，妊娠率存在与年龄相关的下降，而在这种情况下，不一定预期存在子宫内膜因素；这种子宫内膜因素似乎与子宫内膜厚度无关。因此，我们的数据支持存在一种无法通过厚度测量评估的子宫内膜因素，但它在胚胎着床成功中起着至关重要的作用。
不适用。
