BACKGROUND: Team-based, interprofessional primary care models are arguably well positioned to care for patients with polypharmacy as they often have a pharmacist or allied health professionals to support patients with medication management. However, little is known about how teams work together to manage medications. This study aimed to explore how a team-based primary care organization including a mix of physicians and interdisciplinary health providers (IHPs), called Family Health Teams (FHTs), manage medications for older adults. METHODS: We conducted semi-structured interviews (n = 38) with administrators, family physicians, and IHPs from six FHTs in Ontario, Canada. We followed the thematic analysis steps outlined by Braun and Clarke and adapted the approach to use a codebook. RESULTS: Four themes were identified: (1) strategic goals and internal policies; (2) tailored programs and supports; (3) diverse team configurations and roles; and (4) teamwork and collaboration. Findings revealed variation in the ways physicians and IHPs worked together to manage medications for older adults and that different approaches to care and physician communication preferences were identified as challenges to medication management. Trust was an important factor in medication management among teams; the more physicians interacted with IHPs, the more comfortable and trusting they were in giving them an active role in patient care. Regardless of the approach to medication management, participants agreed that physicians ultimately had the final say in patient care. CONCLUSIONS: Despite an emphasis on teamwork in FHTs, there were few examples of true collaboration and shared care for medication management. To support older adults and others with complex health needs, opportunities to improve teamwork, strengthen collaboration, and optimize team composition should be identified and pursued.