Han Shunshun, Wei Yimeng, Wei Yuanhang, Zhao Xiyu, Chen Yuqi, Cui Can, Zhang Yao, Yin Huadong
Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
J Anim Sci Biotechnol. 2025 Aug 3;16(1):109. doi: 10.1186/s40104-025-01241-6.
Programmed cell death (PCD), including autophagy, apoptosis, and ferroptosis, is a fundamental biological process that plays a critical role in follicular development and atresia in livestock. In ovaries, the vast majority of follicles undergo atresia, while only a small fraction reach ovulation. Emerging evidence suggests that these three forms of PCD are intricately involved in regulating follicular fate through distinct yet interconnected molecular mechanisms. This review summarizes recent advances in understanding the roles of autophagy, apoptosis, and ferroptosis in follicular development and atresia, with a focus on their molecular mechanisms and interactions. By elucidating the complex regulatory networks of PCD in ovarian physiology, this review aims to provide new insights into improving reproductive efficiency in livestock through targeted modulation of these pathways.
程序性细胞死亡（PCD），包括自噬、凋亡和铁死亡，是一个基本的生物学过程，在牲畜卵泡发育和闭锁中起着关键作用。在卵巢中，绝大多数卵泡会发生闭锁，只有一小部分能够排卵。新出现的证据表明，这三种形式的程序性细胞死亡通过独特但相互关联的分子机制，复杂地参与调节卵泡命运。本综述总结了在理解自噬、凋亡和铁死亡在卵泡发育和闭锁中的作用方面的最新进展，重点关注它们的分子机制和相互作用。通过阐明卵巢生理学中程序性细胞死亡的复杂调控网络，本综述旨在通过有针对性地调节这些途径，为提高牲畜繁殖效率提供新的见解。
