Nakaya Moto, Kamiya Kouhei, Kurokawa Ryo, Kunimatsu Akira, Suzuki Yuichi, Koike Shinsuke, Okada Naohiro, Kasai Kiyoto, Abe Osamu
Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Radiology, Toho University, Tokyo, Japan.
J Psychiatr Res. 2025 Sep;189:505-512. doi: 10.1016/j.jpsychires.2025.07.006. Epub 2025 Jul 30.
Bipolar disorder (BD) is often associated with extensive changes in white matter (WM) microstructure. While diffusion tensor imaging (DTI) has been used in BD studies, diffusion kurtosis imaging (DKI) has rarely been explored, particularly concerning the different subtypes of BD. This cross-sectional study compared DTI and DKI metrics of the brain WM in participants with BD type I (BD-I) and II (BD-II) and in healthy controls (HC). The correlation between the diffusion metrics and the clinical scores was examined. In total, 40 patients with BD and 42 HC were enrolled. Diffusion metrics across groups were examined using tract-based spatial statistics. Patients with BD-I showed lower fractional anisotropy and kurtosis values throughout the WM compared with the values found in patients with BD-II and HC. Comparison between the BD subtypes suggested that patients with BD-I had more prominent WM disruption. Diffusion kurtosis imaging analyses demonstrated a greater spatial extent of significant effects across different BD subtypes than could be achieved by DTI. Our results indicated that DKI can enhance the sensitivity to WM microstructural alterations in BD and that this technique can provide valuable insights into the biological differences between BD-I and BD-II.
双相情感障碍（BD）常与白质（WM）微观结构的广泛变化相关。虽然扩散张量成像（DTI）已用于BD研究，但扩散峰度成像（DKI）很少被探索，尤其是关于BD的不同亚型。这项横断面研究比较了I型双相情感障碍（BD-I）和II型双相情感障碍（BD-II）患者以及健康对照（HC）的脑白质DTI和DKI指标。研究了扩散指标与临床评分之间的相关性。总共招募了40名BD患者和42名HC。使用基于束的空间统计学检查各组间的扩散指标。与BD-II患者和HC相比，BD-I患者在整个白质中的各向异性分数和峰度值较低。BD亚型之间的比较表明，BD-I患者的白质破坏更为明显。扩散峰度成像分析显示，与DTI相比，不同BD亚型的显著效应在空间上的范围更大。我们的结果表明，DKI可以提高对BD中白质微观结构改变的敏感性，并且该技术可以为BD-I和BD-II之间的生物学差异提供有价值的见解。
