Jacko Georgina, Sivakaanthan Aarany, Cunningham Peter, Daly James, Liley Helen
Pathology and Clinical Governance, Australian Red Cross Lifeblood, Brisbane, Queensland, Australia.
Paediatric Department, Children's Health Queensland, Brisbane, Queensland, Australia.
Vox Sang. 2025 Sep;120(9):921-927. doi: 10.1111/vox.70065. Epub 2025 Aug 3.
Despite many known benefits of red blood cell (RBC) transfusions for very low birth weight (VLBW) infants, there is increasing concern that they may be associated with adverse clinical outcomes and that donor characteristics (including donor sex) could contribute to these adverse outcomes.
Outcomes of a 7-year (2016-2022) retrospective cohort of VLBW preterm infants born at Mater Mothers' Hospital who received at least one RBC transfusion and no other blood products were assessed. While adjusting for the number of transfusions administered to each neonate, we investigated the association between donor sex (expressed as the proportion of transfused RBC units collected from female donors) and standardized morbidity outcomes that are reported to the Australian and New Zealand Neonatal Network. These outcomes include bronchopulmonary dysplasia, late onset infection, retinopathy of prematurity and mortality.
Analysis including 394 neonates who received a total of 820 RBC transfusions did not identify any statistically significant associations between blood donor sex and the outcomes of interest.
Our findings support the continued practice of administration of RBC transfusions to Australian VLBW neonates without consideration of blood donor sex. Further large, prospective, multi-centre studies are recommended to enhance the level of evidence addressing this clinical concern.
尽管红细胞（RBC）输注对极低出生体重（VLBW）婴儿有诸多已知益处，但人们越来越担心其可能与不良临床结局相关，且供者特征（包括供者性别）可能导致这些不良结局。
对在马特母亲医院出生的接受至少一次RBC输注且未接受其他血液制品的VLBW早产儿进行了为期7年（2016 - 2022年）的回顾性队列研究，评估其结局。在调整每个新生儿输注次数的同时，我们调查了供者性别（以从女性供者采集的输注RBC单位比例表示）与向澳大利亚和新西兰新生儿网络报告的标准化发病结局之间的关联。这些结局包括支气管肺发育不良、晚发性感染、早产儿视网膜病变和死亡率。
对394名共接受820次RBC输注的新生儿进行分析，未发现供血者性别与感兴趣的结局之间存在任何统计学上的显著关联。
我们的研究结果支持在不考虑供血者性别的情况下，继续对澳大利亚VLBW新生儿进行RBC输注。建议进一步开展大型、前瞻性、多中心研究，以提高解决这一临床问题的证据水平。
