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mTOR inhibition sensitizes T-ALL cells to Venetoclax through engagement of the integrated stress response.

作者信息

Urso Loredana, Bertazzolo Irene, Corradin Alberto, Silic-Benussi Micol, Minuzzo Sonia A, D'Agostino Donna M, Ciminale Vincenzo

机构信息

Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

University of Padova, Padova, Italy.

出版信息

Signal Transduct Target Ther. 2025 Aug 4;10(1):246. doi: 10.1038/s41392-025-02368-8.

DOI:10.1038/s41392-025-02368-8
PMID:40754585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12319092/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f31/12319092/84765ed3e717/41392_2025_2368_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f31/12319092/84765ed3e717/41392_2025_2368_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f31/12319092/84765ed3e717/41392_2025_2368_Fig1_HTML.jpg

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本文引用的文献

1
mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells.mTOR抑制作用下调6-磷酸葡萄糖脱氢酶并诱导T细胞急性淋巴细胞白血病细胞发生活性氧依赖性死亡。
Redox Biol. 2022 May;51:102268. doi: 10.1016/j.redox.2022.102268. Epub 2022 Feb 24.
2
How I treat newly diagnosed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma in children.我如何治疗儿童新诊断的 T 细胞急性淋巴细胞白血病和 T 细胞淋巴母细胞淋巴瘤。
Blood. 2020 Jan 16;135(3):159-166. doi: 10.1182/blood.2019001557.
3
The integrated stress response.
整合应激反应
EMBO Rep. 2016 Oct;17(10):1374-1395. doi: 10.15252/embr.201642195. Epub 2016 Sep 14.
4
Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.T细胞急性淋巴细胞白血病的成熟阶段决定了对BCL-2与BCL-XL的依赖性以及对ABT-199的敏感性。
Cancer Discov. 2014 Sep;4(9):1074-87. doi: 10.1158/2159-8290.CD-14-0353. Epub 2014 Jul 3.
5
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.由死亡信号引发的线粒体决定细胞对抗凋亡BCL-2家族成员的依赖性。
Cancer Cell. 2006 May;9(5):351-65. doi: 10.1016/j.ccr.2006.03.027.