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[1983年布基纳法索黄热病流行期间稳定化黄热病疫苗17D的使用情况]

[Use of stabilized yellow fever vaccine 17D at the time of the yellow fever epidemic in Burkina Faso in 1983].

作者信息

Saluzzo J F, Some L, Baudon D, Girault G, Lhuillier M, Kambire P A, Roux J F, Digoutte J P

出版信息

Bull Soc Pathol Exot Filiales. 1985;78(4):536-40.

PMID:4075474
Abstract

During the 1983 yellow fever epidemic in Burkina Faso, vaccinations were performed with a stabilized yellow fever 17D vaccine. Samples of vaccine were collected in different places during the vaccination campaigns. The virus titers of these samples were compared with those of vaccine samples of the same batches stored at--20 degree C in the Institut Pasteur in Dakar. There was no significant decrease of the titer when the vaccine had been stored in the conditions recommended by the expanded programme on immunization. The results confirm the experimental data on the stability of this vaccine. A serological survey carried out in young children showed that about 90% have hemagglutination inhibition antibodies following the vaccination.

摘要

1983年布基纳法索黄热病疫情期间,使用了一种稳定化的黄热病17D疫苗进行接种。在疫苗接种活动期间,于不同地点采集了疫苗样本。将这些样本的病毒滴度与在达喀尔巴斯德研究所保存在-20摄氏度的同一批次疫苗样本的病毒滴度进行了比较。当疫苗按照扩大免疫规划建议的条件储存时,滴度没有显著下降。这些结果证实了关于该疫苗稳定性的实验数据。对幼儿进行的血清学调查显示,接种疫苗后约90%的儿童产生了血凝抑制抗体。

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