Kang Eunseok, Haque Rosa, Lee Hanseul, Lee Seung-Jae V
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
BMB Rep. 2025 Aug 4.
RNA modifications are key epigenetic alterations that play regulatory functions in RNA biology, including RNA stability and translation. Emerging evidence indicates that RNA modification is crucial for various physiological and pathological processes, including aging. This review describes functions of key RNA modifications, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), 2'-O-methylation (Nm), N1-methyladenosine (m1A), adenosine-to-inosine (A-to-I) RNA editing, pseudouridylation (ψ), and N4-acetylcytidine (ac4C), highlighting their roles in aging and age-associated diseases. We also discuss dynamics of RNA modifications and associated protein factors during aging. This review provides important information on molecular mechanisms underlying aging regulation, focusing on effects of RNA modifications, which can help us understand healthy longevity in humans.
RNA修饰是关键的表观遗传改变，在RNA生物学中发挥调控功能，包括RNA稳定性和翻译。新出现的证据表明，RNA修饰对于包括衰老在内的各种生理和病理过程至关重要。本综述描述了关键RNA修饰的功能，包括N6-甲基腺苷（m6A）、5-甲基胞嘧啶（m5C）、N7-甲基鸟苷（m7G）、2'-O-甲基化（Nm）、N1-甲基腺苷（m1A）、腺苷到肌苷（A-to-I）RNA编辑、假尿苷化（ψ）和N4-乙酰胞苷（ac4C），强调了它们在衰老和与年龄相关疾病中的作用。我们还讨论了衰老过程中RNA修饰和相关蛋白质因子的动态变化。本综述提供了关于衰老调控潜在分子机制的重要信息，重点关注RNA修饰的影响，这有助于我们理解人类的健康长寿。
