Farmer Chantal, Johannsen Jakob C, Huber Lee-Anne
Agriculture and Agri-Food Canada, Sherbrooke Research and Development Centre, 2000 College, Sherbrooke, QC, Canada J1M 0C8.
Aarhus University, Department of Animal and Veterinary Sciences, Blichers Allé 20, DK-8830 Tjele, Denmark; and.
J Anim Sci. 2025 Jul 31. doi: 10.1093/jas/skaf246.
The aim of this project was to determine the impact of either increasing standardized ileal digestible (SID) Lys intake by 40% in gilts from days 85 to 111 of gestation, or combining that treatment with an increase in prolactin concentrations during lactation, on sow and piglet performances. On day 85 of gestation gilts were divided in three groups: 1) fed SID Lys at estimated NRC requirement (CTL, control, n =23) until day 111 of gestation, 2) fed SID Lys at 40% above requirement via additional soybean meal (LYS, n = 22) until day 111 of gestation, or 3) fed SID Lys at 40% above requirement via additional soybean meal (LYSDOMP, n = 21) until day 111 of gestation and receiving domperidone throughout lactation. Experimental diets were isoenergetic. The LYSDOMP sows were injected daily with the dopamine receptor antagonist domperidone (0.5 mg/kg body weight, BW) from the day after farrowing until weaning. Additionally, they were fed 0.5 mg/kg BW of domperidone twice daily for the first 4 d of lactation. The CTL and LYS sows received injections and per os treatment with the vehicle. Litter size was standardized to 12 ± 1 and piglets were weighed on days 1, 7 and 22. Sow feed intake was recorded daily. Blood samples were collected on days 84 and 110 of gestation and days 1, 7, and 21 of lactation to measure prolactin, IGF-I, urea, free fatty acids (FFA), glucose (gestation only) and amino acids (gestation only). Milk samples were obtained on day 7 of lactation. Sow BW and backfat thickness throughout the study and feed intake in lactation were not affected by treatments (P > 0.10). Prolactin concentrations were greater for LYSDOMP compared with CTL and LYS sows on days 7 and 21 (P < 0.0001). Treatments did not alter IGF-I, glucose, or FFA concentrations at any time (P > 0.05) and urea was greater in LYS and LYSDOMP than CTL sows on day 110 of gestation (P < 0.05). Estimated milk yield or piglet growth rate were not affected by treatments (P > 0.10). In conclusion, feeding supplementary Lys (protein) in late gestation either with or without domperidone in lactation did not increase sow milk yield. Findings emphasize that a greater litter size was likely needed to see beneficial effects of supplementary Lys, and that the use of primiparous sows or inadequate lactational feed intake may have impeded effects of the domperidone.
本项目的目的是确定在妊娠第85至111天，将后备母猪的标准回肠可消化（SID）赖氨酸摄入量提高40%，或将该处理与哺乳期催乳素浓度升高相结合，对母猪和仔猪性能的影响。在妊娠第85天，将后备母猪分为三组：1）按照估计的NRC需求量饲喂SID赖氨酸（CTL，对照组，n = 23）直至妊娠第111天，2）通过额外添加豆粕以高于需求量40%的量饲喂SID赖氨酸（LYS，n = 22）直至妊娠第111天，或3）通过额外添加豆粕以高于需求量40%的量饲喂SID赖氨酸（LYSDOMP，n = 21）直至妊娠第111天，并在整个哺乳期接受多潘立酮。实验日粮能量相等。LYSDOMP组母猪从分娩后第二天直至断奶，每天注射多巴胺受体拮抗剂多潘立酮（0.5 mg/kg体重，BW）。此外，在哺乳期的前4天，它们每天两次口服0.5 mg/kg BW的多潘立酮。CTL组和LYS组母猪接受注射及用赋形剂进行口服处理。产仔数标准化为12±1头，在第1、7和22天对仔猪称重。每天记录母猪的采食量。在妊娠第84和110天以及哺乳期第1、7和21天采集血样，以测定催乳素、胰岛素样生长因子-I（IGF-I）、尿素、游离脂肪酸（FFA）、葡萄糖（仅在妊娠期）和氨基酸（仅在妊娠期）。在哺乳期第7天采集乳样。在整个研究过程中，母猪的体重和背膘厚度以及哺乳期的采食量不受处理影响（P>0.10）。与CTL组和LYS组母猪相比，LYSDOMP组母猪在第7和21天的催乳素浓度更高（P<0.0001）。各处理在任何时候均未改变IGF-I、葡萄糖或FFA浓度（P>0.05），在妊娠第110天，LYS组和LYSDOMP组母猪的尿素含量高于CTL组母猪（P<0.05）。估计的产奶量或仔猪生长率不受处理影响（P>0.10）。总之，在妊娠后期饲喂补充赖氨酸（蛋白质），无论哺乳期是否使用多潘立酮，均未提高母猪的产奶量。研究结果强调，可能需要更大的窝产仔数才能看到补充赖氨酸的有益效果，并且初产母猪的使用或哺乳期采食量不足可能阻碍了多潘立酮的作用。
