Roberts J P, Perry M O, Hariri R J, Shires G T
Circ Shock. 1985;17(3):253-8.
A simultaneous comparison of the effect of partial and total ischemia on skeletal muscle was made in dogs. The totally ischemic muscle had larger changes in adenosine triphosphate (ATP), creatine phosphate (CP), and cellular transmembrane potential difference (PD) during the 3-hour ischemic period than the partially ischemic muscle. Following recovery, all measured parameters in the totally ischemic muscle returned to normal, but paradoxically the PD in the partially ischemic muscle remained depressed despite the return to normal levels of ATP and CP. Contrary to the results in partially and totally ischemic brain tissue there was no evidence for higher levels of lactic acid in the partially ischemic muscle that could explain the persistent alteration in muscle cell function.
在犬类中对部分缺血和完全缺血对骨骼肌的影响进行了同步比较。在3小时的缺血期内，完全缺血的肌肉中三磷酸腺苷（ATP）、磷酸肌酸（CP）和细胞跨膜电位差（PD）的变化比部分缺血的肌肉更大。恢复后，完全缺血肌肉中的所有测量参数均恢复正常，但矛盾的是，尽管ATP和CP恢复到正常水平，部分缺血肌肉中的PD仍处于降低状态。与部分缺血和完全缺血脑组织的结果相反，没有证据表明部分缺血肌肉中乳酸水平升高，而这可以解释肌肉细胞功能的持续改变。
