[The effect of arteriovenous fistulas on the metabolism and morphology of striated muscles].

The revascularization of ischemic extremities by retrograde arterial perfusion has been reported in clinical and experimental studies. The effect of retrograde perfusion on hemodynamics and metabolism of skeletal muscle was investigated in 86 rabbits with various types of AV-fistulas. Since blood flow was markedly reduced, levels of energy phosphates (ATP, CP) stabilized on a lower level. In all groups, lactate raised significantly. Focal morphological lesions were seen in all groups in a various degree. A high incidence of thrombosis was found at dissection. Maintenance of blood flow and metabolism after retrograde perfusion seems to be possible on a low level.