干血斑中的替诺福韦二磷酸浓度可预测青少年HIV感染者未来的病毒抑制情况，但无法预测病毒学失败情况。
Tenofovir diphosphate concentrations in dried blood spots predict future HIV suppression but not virologic failure in adolescents with HIV.
作者信息
Antwi Sampson, Yang Hongmei, Enimil Anthony, Martyn-Dickens Charles, Dompreh Albert, Sly-Moore Eugenia, Bosomtwe Dennis, Amissah Aikins Kofi, Ojewale Oluwayemisi, Asiedu Priscilla, Appiah Augustina Frimpong, Opoku Theresah, Sarfo Ama D, Kusi-Amponsah Isaac, Bushman Lane R, Ellison Lucas, Anderson Peter L, Kwara Awewura
机构信息
Department of Child Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi.
Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
出版信息
AIDS. 2025 Sep 1;39(11):1668-1671. doi: 10.1097/QAD.0000000000004245. Epub 2025 Jul 31.
We investigated whether tenofovir diphosphate (TFV-DP) concentration in dried blood spot (DBS) predicted future virologic outcome. Of 52 adolescents with HIV, 46% had virologic suppression, and 44% had virologic failure. TFV-DP concentration in DBS was associated with virologic suppression but not virologic failure. Twenty-six percentage of participants with virologic failure had high levels of antiretroviral adherence at earlier visits. Virologic failure in the setting of high adherence may suggest the presence of HIV drug resistance.
我们研究了干血斑（DBS）中替诺福韦二磷酸酯（TFV-DP）浓度是否能预测未来的病毒学结果。在52名感染艾滋病毒的青少年中，46%实现了病毒学抑制，44%出现了病毒学失败。DBS中的TFV-DP浓度与病毒学抑制相关，但与病毒学失败无关。26%出现病毒学失败的参与者在早期就诊时抗逆转录病毒治疗依从性较高。高依从性情况下的病毒学失败可能提示存在艾滋病毒耐药性。
Zotero 插件