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干血斑中的替诺福韦二磷酸浓度可预测青少年HIV感染者未来的病毒抑制情况，但无法预测病毒学失败情况。

Tenofovir diphosphate concentrations in dried blood spots predict future HIV suppression but not virologic failure in adolescents with HIV.

作者信息

Antwi Sampson, Yang Hongmei, Enimil Anthony, Martyn-Dickens Charles, Dompreh Albert, Sly-Moore Eugenia, Bosomtwe Dennis, Amissah Aikins Kofi, Ojewale Oluwayemisi, Asiedu Priscilla, Appiah Augustina Frimpong, Opoku Theresah, Sarfo Ama D, Kusi-Amponsah Isaac, Bushman Lane R, Ellison Lucas, Anderson Peter L, Kwara Awewura

机构信息

Department of Child Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi.

Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.

出版信息

AIDS. 2025 Sep 1;39(11):1668-1671. doi: 10.1097/QAD.0000000000004245. Epub 2025 Jul 31.

DOI:10.1097/QAD.0000000000004245
PMID:40755217
Abstract

We investigated whether tenofovir diphosphate (TFV-DP) concentration in dried blood spot (DBS) predicted future virologic outcome. Of 52 adolescents with HIV, 46% had virologic suppression, and 44% had virologic failure. TFV-DP concentration in DBS was associated with virologic suppression but not virologic failure. Twenty-six percentage of participants with virologic failure had high levels of antiretroviral adherence at earlier visits. Virologic failure in the setting of high adherence may suggest the presence of HIV drug resistance.

摘要

我们研究了干血斑（DBS）中替诺福韦二磷酸酯（TFV-DP）浓度是否能预测未来的病毒学结果。在52名感染艾滋病毒的青少年中，46%实现了病毒学抑制，44%出现了病毒学失败。DBS中的TFV-DP浓度与病毒学抑制相关，但与病毒学失败无关。26%出现病毒学失败的参与者在早期就诊时抗逆转录病毒治疗依从性较高。高依从性情况下的病毒学失败可能提示存在艾滋病毒耐药性。

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1
Tenofovir diphosphate concentrations in dried blood spots predict future HIV suppression but not virologic failure in adolescents with HIV.干血斑中的替诺福韦二磷酸浓度可预测青少年HIV感染者未来的病毒抑制情况，但无法预测病毒学失败情况。
AIDS. 2025 Sep 1;39(11):1668-1671. doi: 10.1097/QAD.0000000000004245. Epub 2025 Jul 31.
2
Moderately High Tenofovir Diphosphate in Dried Blood Spots Indicates Drug Resistance in Viremic Persons Living with HIV.干血斑中替诺福韦二磷酸水平中度升高表明HIV病毒血症患者存在耐药性。
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本文引用的文献

1
Pharmacokinetics of Tenofovir Diphosphate, Lamivudine Triphosphate and Emtricitabine Triphosphate in Adolescents With HIV Infection With and Without Tuberculosis Coinfection.伴有或不伴有结核合并感染的HIV感染青少年中替诺福韦二磷酸、拉米夫定三磷酸和恩曲他滨三磷酸的药代动力学
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Viral suppression and adherence in adolescents living with HIV in rural Tanzania.坦桑尼亚农村地区感染艾滋病毒青少年的病毒抑制情况及依从性
PLoS One. 2024 Dec 20;19(12):e0315866. doi: 10.1371/journal.pone.0315866. eCollection 2024.
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Longitudinal Trajectories of Antiretroviral Treatment Adherence and Associations With Durable Viral Suppression Among Adolescents Living With HIV in South Africa.
南非艾滋病毒感染者青少年抗逆转录病毒治疗依从性的纵向轨迹及其与持久病毒抑制的相关性。
J Acquir Immune Defic Syndr. 2024 Jun 1;96(2):171-179. doi: 10.1097/QAI.0000000000003408.
4
Relationship Between Tenofovir Diphosphate Concentrations in Dried Blood Spots and Virological Outcomes After Initiating Tenofovir-Lamivudine-Dolutegravir as First-Line or Second-Line Antiretroviral Therapy.干血斑中替诺福韦二吡呋酯浓度与一线或二线抗逆转录病毒治疗起始后替诺福韦-拉米夫定-多替拉韦的病毒学结局的关系。
J Acquir Immune Defic Syndr. 2024 Mar 1;95(3):260-267. doi: 10.1097/QAI.0000000000003341.
5
Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa.干血斑中替诺福韦二磷酸盐与南非的 HIV-1 耐药性。
AIDS Res Ther. 2023 Sep 14;20(1):67. doi: 10.1186/s12981-023-00552-w.
6
Tenofovir diphosphate in dried blood spots predicts future viremia in persons with HIV taking antiretroviral therapy in South Africa.干血斑中的替诺福韦二磷酸盐可预测南非接受抗逆转录病毒治疗的 HIV 感染者的未来病毒血症。
AIDS. 2022 Jun 1;36(7):933-940. doi: 10.1097/QAD.0000000000003185. Epub 2022 Feb 16.
7
Use of Tenofovir Diphosphate Levels to Predict Viremia During the Postpartum Period in Women Living With Human Immunodeficiency Virus (HIV): A Nested Case-Control Study.利用替诺福韦二磷酸水平预测人类免疫缺陷病毒（HIV）感染者产后病毒血症：一项巢式病例对照研究。
Clin Infect Dis. 2022 Sep 14;75(5):761-767. doi: 10.1093/cid/ciab1068.
8
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J Int AIDS Soc. 2021 Dec;24(12):e25849. doi: 10.1002/jia2.25849.
9
Alarming rates of virological failure and HIV-1 drug resistance amongst adolescents living with perinatal HIV in both urban and rural settings: evidence from the EDCTP READY-study in Cameroon.在城市和农村地区，围生期感染 HIV 的青少年中病毒学失败和 HIV-1 耐药的惊人发生率：来自喀麦隆 EDCTP READY 研究的证据。
HIV Med. 2021 Aug;22(7):567-580. doi: 10.1111/hiv.13095. Epub 2021 Mar 31.
10
Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots Following Tenofovir Alafenamide: The TAF-DBS Study.替诺福韦艾拉酚胺治疗后干血斑中细胞内替诺福韦二磷酸和恩曲他滨三磷酸：TAF-DBS 研究。
J Acquir Immune Defic Syndr. 2020 Jul 1;84(3):323-330. doi: 10.1097/QAI.0000000000002354.