Mouradian M D, Penovich P E
Clin Electroencephalogr. 1985 Oct;16(4):213-8. doi: 10.1177/155005948501600409.
A forty-two year old female with known alcoholic liver disease was given intravenous lorazepam and diazepam for delirium tremens. This resulted in a comatose state with depression of some brainstem reflexes. Her initial EEG showed a pattern of spindle coma with some responsivity of the background. Clinical improvement occurred with cessation of the benzodiazepines and the EEG showed a return to normal patterns. A review of the literature showed no previous description of this pattern in benzodiazepine coma. Two reports of spindle coma are noted with alcohol and imipramine. The prognostic significance of this pattern in drug overdose is therefore not definitive by itself. Outcome is probably more dependent on the clinical condition of the patient and the reversibility of the drug toxicity.
一名患有酒精性肝病的42岁女性因震颤谵妄接受了静脉注射劳拉西泮和地西泮治疗。这导致了昏迷状态，伴有一些脑干反射抑制。她最初的脑电图显示为纺锤体昏迷模式，背景有一定反应性。停用苯二氮䓬类药物后临床症状改善，脑电图显示恢复正常模式。文献回顾显示，此前没有关于苯二氮䓬类药物昏迷中这种模式的描述。有两份关于酒精和丙咪嗪导致纺锤体昏迷的报告。因此，这种模式在药物过量中的预后意义本身并不明确。结果可能更多地取决于患者的临床状况和药物毒性的可逆性。
