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孟德尔随机化分析揭示饮料与肠易激综合征之间的因果关联：是酒精，而非其他饮料。

Mendelian Randomization Analysis Reveals Causal Associations Between Beverages and Irritable Bowel Syndrome: Alcohol, but Not Others.

作者信息

Yuan Ruiqing, Zhou Yajing, Ren Yujie, Hou Xiaohua, Zhu Siran

机构信息

Division of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China.

Department of Respiratory and Critical Care Medicine National Clinical Research Center of Respiratory Disease, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College and State Key Laboratory of Pulm, Huazhong University of Science and Technology Wuhan China.

出版信息

Food Sci Nutr. 2025 Jul 31;13(8):e70761. doi: 10.1002/fsn3.70761. eCollection 2025 Aug.

DOI:10.1002/fsn3.70761
PMID:40755502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12313541/
Abstract

Observational studies have suggested that beverage intake could have potential connections with irritable bowel syndrome (IBS). However, the association patterns and the underlying mechanisms remain unknown. The study identified potential causal relationships between alcohol intake and IBS, showing positive associations for alcohol intake frequency (odds ratio = 1.18, 95% confidence interval = 1.09-1.26;  < 0.001). Psychiatric disorders were found to play mediative roles with mediation effects of 25.22%, 45.77%, and 12.10% for depression (broad), major depression disease, and attention deficit hyperactivity disorder, respectively. These findings suggest that reducing alcohol intake may help prevent IBS, especially in individuals with psychiatric conditions.

摘要

观察性研究表明，饮料摄入可能与肠易激综合征（IBS）存在潜在联系。然而，关联模式和潜在机制仍不清楚。该研究确定了酒精摄入与IBS之间的潜在因果关系，显示酒精摄入频率呈正相关（优势比=1.18，95%置信区间=1.09-1.26；<0.001）。研究发现，精神障碍起到中介作用，对广泛性抑郁、重度抑郁症和注意力缺陷多动障碍的中介效应分别为25.22%、45.77%和12.10%。这些发现表明，减少酒精摄入可能有助于预防IBS，尤其是对有精神疾病的个体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c281/12313541/ff8cb1c2d835/FSN3-13-e70761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c281/12313541/fef44bb00cd1/FSN3-13-e70761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c281/12313541/8c3550c2b6ce/FSN3-13-e70761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c281/12313541/ff8cb1c2d835/FSN3-13-e70761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c281/12313541/fef44bb00cd1/FSN3-13-e70761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c281/12313541/8c3550c2b6ce/FSN3-13-e70761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c281/12313541/ff8cb1c2d835/FSN3-13-e70761-g004.jpg

相似文献

[1]
Mendelian Randomization Analysis Reveals Causal Associations Between Beverages and Irritable Bowel Syndrome: Alcohol, but Not Others.

Food Sci Nutr. 2025-7-31

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
The journey between brain and gut: A systematic review of psychological mechanisms of treatment effect in irritable bowel syndrome.

Br J Health Psychol. 2017-6-1

[10]
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis.

Genome Med. 2023-8-1

本文引用的文献

[1]
Addressing the credibility crisis in Mendelian randomization.

BMC Med. 2024-9-11

[2]
Functional Gastrointestinal Symptoms in Children with Autism and ADHD: Profiles of Hair and Salivary Cortisol, Serum Leptin Concentrations and Externalizing/Internalizing Problems.

Nutrients. 2024-5-20

[3]
Genetic associations and potential mediators between psychiatric disorders and irritable bowel syndrome: a Mendelian randomization study with mediation analysis.

Front Psychiatry. 2024-1-30

[4]
Food Intolerances, Food Allergies and IBS: Lights and Shadows.

Nutrients. 2024-1-16

[5]
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes.

Neoplasia. 2023-12

[6]
Common Variants on Increase Hazard of Mortality or Rehospitalization in Patients With Heart Failure From the ASCEND-HF Trial.

Circ Heart Fail. 2023-9

[7]
Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies.

Nat Genet. 2023-9

[8]
Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study.

Lancet Neurol. 2023-11

[9]
Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study.

J Transl Med. 2023-5-31

[10]
Assessing the relationship between gut microbiota and irritable bowel syndrome: a two-sample Mendelian randomization analysis.

BMC Gastroenterol. 2023-5-12

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