Mukhtar Farrah
Obstetrics and Gynaecology, George Eliot Hospital, Nuneaton, GBR.
Cureus. 2025 Jul 3;17(7):e87258. doi: 10.7759/cureus.87258. eCollection 2025 Jul.
Maternal obesity is a looming worldwide health challenge with dire consequences regarding pregnancy outcomes and future maternal and offspring health. This systematic review synthesizes evidence from eight high-quality studies published between 2015 and 2024, discussing the management of maternal obesity during pregnancy, antenatal care strategies, associated perinatal outcomes, and long-term maternal health risks. The review identifies a strong correlation between maternal obesity and the increased chances for gestational diabetes mellitus (GDM), hypertensive disorders, preterm birth, cesarean delivery, and neonatal morbidity, including large for gestational age (LGA) infants and congenital anomalies. Moreover, there are long-term maternal impacts of increased chances for type 2 diabetes mellitus and cardiovascular disorders. Also, there is an increased risk of metabolic and neurodevelopmental disorders for the offspring. There are significant differences in the antenatal management strategies in settings with conflicting clinical guidelines on the issues of gestational weight gain, screening protocols, and lifestyle counseling. The early pregnancy holds promises in the improvement of outcomes in multidisciplinary interventions, but implementation is still limited. A predictive risk model based on maternal comorbidities, age, and pattern of fat distribution may provide a foundation for individual treatment and needs to be validated. As outlined in the review, the need for standardized and evidence-based guidelines for coordinated antenatal care is emphasized to reduce the harmful effects of maternal obesity. It is crucial not only for the improvement of maternal and neonatal outcomes but also from the viewpoint of breaking the intergenerational cycle of obesity- related health issues.
孕产妇肥胖是一个迫在眉睫的全球性健康挑战,对妊娠结局以及未来母亲和后代的健康会产生严重后果。本系统综述综合了2015年至2024年间发表的八项高质量研究的证据,讨论了孕期孕产妇肥胖的管理、产前护理策略、相关围产期结局以及长期的孕产妇健康风险。该综述指出,孕产妇肥胖与妊娠期糖尿病(GDM)、高血压疾病、早产、剖宫产以及新生儿发病几率增加之间存在密切关联,这些新生儿发病情况包括大于胎龄(LGA)婴儿和先天性异常。此外,患2型糖尿病和心血管疾病的几率增加对母亲有长期影响。而且,后代患代谢和神经发育障碍的风险也会增加。在妊娠体重增加、筛查方案和生活方式咨询等问题上,临床指南相互冲突,不同环境下的产前管理策略存在显著差异。妊娠早期在多学科干预改善结局方面具有前景,但实施仍然有限。基于孕产妇合并症、年龄和脂肪分布模式的预测风险模型可能为个体化治疗提供基础,尚需验证。如综述所述,强调需要有标准化且基于证据的指南来协调产前护理,以减少孕产妇肥胖的有害影响。这不仅对改善孕产妇和新生儿结局至关重要,而且从打破肥胖相关健康问题的代际循环角度来看也至关重要。