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孕期孕产妇肥胖管理的系统评价:产前管理、结局及对孕产妇健康的长期影响

A Systematic Review of the Management of Maternal Obesity in Pregnancy: Antenatal Management, Outcomes, and Long-Term Implications on Maternal Health.

作者信息

Mukhtar Farrah

机构信息

Obstetrics and Gynaecology, George Eliot Hospital, Nuneaton, GBR.

出版信息

Cureus. 2025 Jul 3;17(7):e87258. doi: 10.7759/cureus.87258. eCollection 2025 Jul.

DOI:10.7759/cureus.87258
PMID:40755671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12318269/
Abstract

Maternal obesity is a looming worldwide health challenge with dire consequences regarding pregnancy outcomes and future maternal and offspring health. This systematic review synthesizes evidence from eight high-quality studies published between 2015 and 2024, discussing the management of maternal obesity during pregnancy, antenatal care strategies, associated perinatal outcomes, and long-term maternal health risks. The review identifies a strong correlation between maternal obesity and the increased chances for gestational diabetes mellitus (GDM), hypertensive disorders, preterm birth, cesarean delivery, and neonatal morbidity, including large for gestational age (LGA) infants and congenital anomalies. Moreover, there are long-term maternal impacts of increased chances for type 2 diabetes mellitus and cardiovascular disorders. Also, there is an increased risk of metabolic and neurodevelopmental disorders for the offspring. There are significant differences in the antenatal management strategies in settings with conflicting clinical guidelines on the issues of gestational weight gain, screening protocols, and lifestyle counseling. The early pregnancy holds promises in the improvement of outcomes in multidisciplinary interventions, but implementation is still limited. A predictive risk model based on maternal comorbidities, age, and pattern of fat distribution may provide a foundation for individual treatment and needs to be validated. As outlined in the review, the need for standardized and evidence-based guidelines for coordinated antenatal care is emphasized to reduce the harmful effects of maternal obesity. It is crucial not only for the improvement of maternal and neonatal outcomes but also from the viewpoint of breaking the intergenerational cycle of obesity- related health issues.

摘要

孕产妇肥胖是一个迫在眉睫的全球性健康挑战,对妊娠结局以及未来母亲和后代的健康会产生严重后果。本系统综述综合了2015年至2024年间发表的八项高质量研究的证据,讨论了孕期孕产妇肥胖的管理、产前护理策略、相关围产期结局以及长期的孕产妇健康风险。该综述指出,孕产妇肥胖与妊娠期糖尿病(GDM)、高血压疾病、早产、剖宫产以及新生儿发病几率增加之间存在密切关联,这些新生儿发病情况包括大于胎龄(LGA)婴儿和先天性异常。此外,患2型糖尿病和心血管疾病的几率增加对母亲有长期影响。而且,后代患代谢和神经发育障碍的风险也会增加。在妊娠体重增加、筛查方案和生活方式咨询等问题上,临床指南相互冲突,不同环境下的产前管理策略存在显著差异。妊娠早期在多学科干预改善结局方面具有前景,但实施仍然有限。基于孕产妇合并症、年龄和脂肪分布模式的预测风险模型可能为个体化治疗提供基础,尚需验证。如综述所述,强调需要有标准化且基于证据的指南来协调产前护理,以减少孕产妇肥胖的有害影响。这不仅对改善孕产妇和新生儿结局至关重要,而且从打破肥胖相关健康问题的代际循环角度来看也至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3272/12318269/f27f7003bd39/cureus-0017-00000087258-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3272/12318269/f27f7003bd39/cureus-0017-00000087258-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3272/12318269/f27f7003bd39/cureus-0017-00000087258-i01.jpg

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本文引用的文献

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The Impact of Overweight and Obesity on Pregnancy: A Narrative Review of Physiological Consequences, Risks and Challenges in Prenatal Care, and Early Intervention Strategies.超重和肥胖对妊娠的影响:关于生理后果、产前护理中的风险与挑战以及早期干预策略的叙述性综述
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Prevalence and predictors of overweight and obesity among women of childbearing age in the province of Essaouira, Morocco.摩洛哥索维拉省育龄妇女超重和肥胖的患病率及预测因素。
BMC Public Health. 2025 Jan 13;25(1):135. doi: 10.1186/s12889-025-21353-y.
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孕产妇肥胖管理:健康政策的叙事文献综述。
BMC Womens Health. 2024 Sep 18;24(1):520. doi: 10.1186/s12905-024-03342-2.
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BMC Womens Health. 2023 Dec 21;23(1):680. doi: 10.1186/s12905-023-02813-2.
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Implementing weight management during and after pregnancy to reduce diabetes and CVD risk in maternal and child populations.在孕期及产后实施体重管理,以降低母婴群体患糖尿病和心血管疾病的风险。
Proc Nutr Soc. 2025 Feb;84(1):24-35. doi: 10.1017/S0029665123004883. Epub 2023 Dec 1.
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Am J Obstet Gynecol MFM. 2023 Apr;5(4):100874. doi: 10.1016/j.ajogmf.2023.100874. Epub 2023 Jan 20.
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Maternal Obesity-Associated Neonatal Morbidities in Early Newborn Period.新生儿早期与母体肥胖相关的发病率
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Association between maternal adiposity measures and adverse maternal outcomes of pregnancy: Systematic review and meta-analysis.母亲肥胖指标与妊娠不良结局的关系:系统评价和荟萃分析。
Obes Rev. 2022 Jul;23(7):e13449. doi: 10.1111/obr.13449. Epub 2022 Apr 25.
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