Ji Mengyue, Li Maoxuan, Dong Na, Cao Jian, Du Xinru, Xu Ting, Shen Yingxiao, Luo Jiale, Ma Jialin, Li Yuan, Zhou Chunxiao
Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Transl Gastroenterol Hepatol. 2025 Jul 8;10:47. doi: 10.21037/tgh-24-151. eCollection 2025.
Non-alcoholic fatty liver disease (NAFLD) significantly threatens public health. Early diagnosis of NAFLD can prevent adverse outcomes, but the current diagnosis system is still imperfect. Serum markers and their combinations are valuable for detecting diseases, including NAFLD. The advanced lung cancer inflammatory index (ALI) is a comprehensive indicator that reflects the inflammation and nutritional status. Gamma-glutamyl transpeptidase (GGT) is an evaluation index for liver function. This study aims to construct a novel indicator based on ALI and GGT to evaluate NAFLD.
A cross-sectional survey was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. Binary logistic regression model and multivariate logistic regression model were utilized to examine the associations. Stratified and receiver operating characteristic (ROC) curve analyses were applied to confirm whether the dependent and independent variables had stable associations in the population.
This population-based study included 3,905 American adults. According to binary logistic regression analysis, an increase in ALI × GGT was significantly correlated with an increased risk of liver fibrosis, and multivariate logistic regression analysis confirmed that ALI × GGT was an independent risk factor for liver fibrosis. After grouping adjustment, we found that the diagnostic value of ALI × GGT was greater among participants under 50 years of age, women, those with diabetes mellitus or borderline diabetes, those without hypertension, and those without non-alcoholic fatty liver.
Our study revealed a new indicator, ALI × GGT, which could serve as a potential biomarker for early liver fibrosis in specific populations.
非酒精性脂肪性肝病（NAFLD）严重威胁公众健康。NAFLD的早期诊断可预防不良后果，但目前的诊断系统仍不完善。血清标志物及其组合对疾病检测具有重要价值，包括NAFLD。晚期肺癌炎症指数（ALI）是反映炎症和营养状况的综合指标。γ-谷氨酰转肽酶（GGT）是肝功能的评估指标。本研究旨在构建基于ALI和GGT的新型指标以评估NAFLD。
使用2017 - 2018年美国国家健康与营养检查调查（NHANES）的数据进行横断面调查。采用二元逻辑回归模型和多变量逻辑回归模型检验相关性。应用分层分析和受试者工作特征（ROC）曲线分析来确认在总体人群中因变量和自变量是否具有稳定的相关性。
这项基于人群的研究纳入了3905名美国成年人。根据二元逻辑回归分析，ALI×GGT升高与肝纤维化风险增加显著相关，多变量逻辑回归分析证实ALI×GGT是肝纤维化的独立危险因素。分组调整后，我们发现ALI×GGT在50岁以下参与者、女性、患有糖尿病或边缘性糖尿病者、无高血压者以及无非酒精性脂肪肝者中诊断价值更大。
我们的研究揭示了一个新指标ALI×GGT，它可作为特定人群早期肝纤维化的潜在生物标志物。
