Justich Maria Belen, Boogers Alexandra, Lozano Andres M, Fasano Alfonso
Edmond J. Safra Program in Parkinson's disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN and Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
Department of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
Tremor Other Hyperkinet Mov (N Y). 2025 Jul 28;15:33. doi: 10.5334/tohm.963. eCollection 2025.
Deep brain stimulation (DBS) is an increasingly utilized therapy for treating refractory tremor in Parkinson's disease (PD). Remote care can improve patient access to specialized DBS clinics. Here, we present a novel strategy to assess tremor remotely during DBS programming. We report the case of a 65-year-old female diagnosed with PD who showed only partial responsiveness to levodopa. She underwent bilateral subthalamic nucleus DBS surgery and was implanted with an Infinity™ implantable pulse generator with directional leads (Abbott, Chicago, IL, USA). Given that she resided 1,500 km from our center, device programming was performed remotely using the Neurosphere™ Virtual Clinic platform. The patient was instructed to hold her controller in a fixed position until her resting tremor re-emerged, which was visibly evident through a shaking video frame. Stimulation parameters were then optimized until the video frame became still. She reported sustained benefit during follow-up. We propose that this alternative method for remotely assessing upper limb tremor may offer advantages for healthcare providers, allowing them to base stimulation adjustments on visually observable tremor severity.
脑深部电刺激(DBS)是治疗帕金森病(PD)难治性震颤越来越常用的一种疗法。远程护理可改善患者前往专业DBS诊所的就医机会。在此,我们提出一种在DBS程控期间远程评估震颤的新策略。我们报告了一例65岁诊断为PD的女性病例,该患者对左旋多巴仅表现出部分反应。她接受了双侧丘脑底核DBS手术,并植入了带有定向电极的Infinity™植入式脉冲发生器(美国伊利诺伊州芝加哥雅培公司)。鉴于她居住在距离我们中心1500公里处,使用Neurosphere™虚拟诊所平台对设备进行了远程程控。患者被指示将控制器保持在固定位置,直到其静止性震颤再次出现,通过抖动的视频画面可明显观察到。然后优化刺激参数,直到视频画面静止。她在随访期间报告持续受益。我们认为,这种远程评估上肢震颤的替代方法可能对医疗服务提供者具有优势,使他们能够根据视觉上可观察到的震颤严重程度进行刺激调整。