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酷似多种病理实体的透明细胞牙源性癌的诊断困境:一例报告及文献综述

Diagnostic Dilemma of Clear Cell Odontogenic Carcinoma Mimicking Various Pathological Entities: A Case Report and Literature Review.

作者信息

Asiri Zayed, Alshahrani Abdullah, Hameed Mohammad Shahul, Assiri Khalil, Assiri Hassan Ahmed

机构信息

Oral and Maxillofacial Surgery Department Asir Central Hospital Abha Saudi Arabia.

Internship Program, College of Dentistry King Khalid University Abha Saudi Arabia.

出版信息

Clin Case Rep. 2025 Aug 1;13(8):e70752. doi: 10.1002/ccr3.70752. eCollection 2025 Aug.

DOI:10.1002/ccr3.70752
PMID:40756083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12317104/
Abstract

Clear cell odontogenic carcinoma (CCOC) is an extremely rare malignancy presenting as a swelling in the mandibles of females. This disease can be diagnosed based on immunohistochemical markers, including Pan cytokeratin (CK), p63, CK5, smooth muscle actin, calponin, and S-100. Treatment can be multidisciplinary, involving surgical removal, radiotherapy, or chemotherapy.

摘要

透明细胞牙源性癌(CCOC)是一种极为罕见的恶性肿瘤,表现为女性下颌骨肿胀。这种疾病可根据免疫组化标志物进行诊断,包括全细胞角蛋白(CK)、p63、CK5、平滑肌肌动蛋白、钙调蛋白和S-100。治疗可以是多学科的,包括手术切除、放疗或化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf6/12317104/77dbd4d8adb1/CCR3-13-e70752-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf6/12317104/7112c7b7c223/CCR3-13-e70752-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf6/12317104/77dbd4d8adb1/CCR3-13-e70752-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf6/12317104/7112c7b7c223/CCR3-13-e70752-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf6/12317104/77dbd4d8adb1/CCR3-13-e70752-g002.jpg

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本文引用的文献

1
Intraosseous jaw lesions: A 25-year experience.颌骨骨内病变:25年的经验
J Oral Maxillofac Pathol. 2022 Oct-Dec;26(4):595. doi: 10.4103/jomfp.jomfp_284_21. Epub 2022 Dec 22.
2
Clear Cell Odontogenic Carcinoma: A Series of Three Cases.透明细胞牙源性癌:三例报告
Dent J (Basel). 2022 Feb 25;10(3):34. doi: 10.3390/dj10030034.
3
Clear Cell Odontogenic Carcinoma a Systematic Review.透明细胞牙源性癌的系统评价。
Head Neck Pathol. 2022 Sep;16(3):838-848. doi: 10.1007/s12105-021-01383-9. Epub 2021 Oct 7.
4
Radiolucent Jaw Lesions: Imaging Approach.颌骨透射性病变:影像学检查方法
Indian J Radiol Imaging. 2021 Jan;31(1):224-236. doi: 10.1055/s-0041-1729769. Epub 2021 Jun 1.
5
Clear Cell Odontogenic Carcinoma: First Report of Novel EWSR1-CREM Fusion Gene in Case of Long-Term Misdiagnosis.透明细胞牙源性癌:首例长期误诊病例中新发现的 EWSR1-CREM 融合基因报告。
Head Neck Pathol. 2021 Dec;15(4):1391-1398. doi: 10.1007/s12105-021-01302-y. Epub 2021 Feb 22.
6
Clear Cell Odontogenic Carcinoma: a Clinicopathological and Immunocytochemical Analysis.透明细胞牙源性癌:临床病理和免疫细胞化学分析。
Pathol Oncol Res. 2020 Jul;26(3):1559-1564. doi: 10.1007/s12253-019-00741-x. Epub 2019 Sep 3.
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Clear cell odontogenic carcinoma: a rare jaw tumor. A summary of 107 reported cases.透明细胞牙源性癌:一种罕见的颌骨肿瘤。107 例报告病例总结。
Int J Oral Maxillofac Surg. 2019 Nov;48(11):1405-1410. doi: 10.1016/j.ijom.2019.05.006. Epub 2019 Jun 18.
8
Clear cell odontogenic carcinoma: A rare case report with emphasis on differential diagnosis.透明细胞牙源性癌:1例罕见病例报告并着重于鉴别诊断
J Cancer Res Ther. 2017 Apr-Jun;13(2):374-377. doi: 10.4103/0973-1482.187381.
9
Molecular Characterization of Clear Cell Lesions of Head and Neck.头颈部透明细胞病变的分子特征
J Clin Diagn Res. 2016 May;10(5):ZE18-23. doi: 10.7860/JCDR/2016/14394.7867. Epub 2016 May 1.
10
Mandibular clear cell odontogenic carcinoma.下颌透明细胞牙源性癌
World J Surg Oncol. 2015 Sep 24;13:284. doi: 10.1186/s12957-015-0693-4.