Datar Uma Vasant, Kamat Mamata Sharad, Kanitkar Sampada Shriram, Byakodi Sanjay Satappa
Department of Oral Pathology and Microbiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Sangli, Maharashtra, India.
Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital, Sangli, Maharashtra, India.
J Cancer Res Ther. 2017 Apr-Jun;13(2):374-377. doi: 10.4103/0973-1482.187381.
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic malignancy with a female predilection, typically presenting as swelling in anterior region of mandible. CCOC was classified as a malignant neoplasm of odontogenic origin by the WHO in 2005 as it exhibits an aggressive growth pattern, local recurrence, and tendency of distant metastasis. Histologically, CCOC is characterized by sheets and islands of vacuolated/clear cells. Since clear cells are present in few odontogenic tumors, salivary gland neoplasms, and metastatic tumors to the jaws; presence of clear cells in a lesion of head and neck area poses a diagnostic challenge. Knowledge about the clinical course, histopathologic pattern, and immunoprofile of CCOC aids in differentiating it from other clear cell tumors. Herein, we present a case of CCOC in anterior mandibular region of 60-year-old female patient with an emphasis on its differential diagnosis from other clear cell lesions of the jaws.
透明细胞牙源性癌（CCOC）是一种罕见的牙源性恶性肿瘤，女性多见，通常表现为下颌前部肿胀。2005年，世界卫生组织将CCOC归类为牙源性恶性肿瘤，因为它具有侵袭性生长模式、局部复发和远处转移倾向。组织学上，CCOC的特征是成片和岛屿状的空泡状/透明细胞。由于透明细胞在少数牙源性肿瘤、涎腺肿瘤和颌骨转移瘤中存在，因此在头颈部区域病变中出现透明细胞会带来诊断挑战。了解CCOC的临床病程、组织病理学模式和免疫表型有助于将其与其他透明细胞肿瘤区分开来。在此，我们报告一例60岁女性患者下颌前部区域的CCOC病例，重点是将其与颌骨其他透明细胞病变进行鉴别诊断。
