Vintimilla Antonio, Rekieta Abigail
Pacific Northwest University Yakima Washington USA.
South Plains Rehabilitation Hospital Lubbock Texas USA.
Clin Case Rep. 2025 Jul 31;13(8):e70734. doi: 10.1002/ccr3.70734. eCollection 2025 Aug.
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune condition that typically affects middle-aged females and presents with bilateral neurological symptoms. Unilateral presentations are uncommon and often difficult to diagnose. Due to its low incidence, rehabilitation strategies for NMOSD remain understudied, particularly in patients with atypical presentations. This report describes a 34-year-old African American male with a unilateral presentation of seropositive NMOSD. He was admitted to inpatient rehabilitation with significant functional impairments and reduced independence across self-care and mobility tasks. A multidisciplinary, high-intensity rehabilitation program was implemented, incorporating task-specific training and conventional therapies, along with more unconventional interventions such as manual therapy and dry needling. Throughout his stay, the patient progressed steadily in balance, transfers, gait, and daily activities. At discharge, he demonstrated significant improvements in all self-care and functional mobility scores, reflecting meaningful gains in independence. Further research is needed to explore long-term outcomes and to determine optimal rehabilitation strategies for individuals with NMOSD, particularly those with atypical or focal clinical features.
视神经脊髓炎谱系障碍（NMOSD）是一种罕见的自身免疫性疾病，通常影响中年女性，并表现为双侧神经症状。单侧表现并不常见，且往往难以诊断。由于其发病率低，针对NMOSD的康复策略仍未得到充分研究，尤其是在非典型表现的患者中。本报告描述了一名34岁的非裔美国男性，他表现为单侧血清阳性NMOSD。他因严重的功能障碍以及在自我护理和移动任务方面独立性降低而入住住院康复机构。实施了一个多学科、高强度的康复计划，包括特定任务训练和传统疗法，以及更非常规的干预措施，如手法治疗和干针疗法。在他住院期间，患者在平衡、转移、步态和日常活动方面稳步进展。出院时，他在所有自我护理和功能移动评分方面都有显著改善，这反映了其独立性有了有意义的提高。需要进一步研究以探索长期结果，并确定针对NMOSD患者，尤其是那些具有非典型或局灶性临床特征患者的最佳康复策略。
