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本文引用的文献

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Feasibility, safety and efficacy of transcutaneous vagus nerve stimulation in chronic tinnitus: an open pilot study.经皮迷走神经刺激治疗慢性耳鸣的可行性、安全性和有效性：一项开放性初步研究。
Brain Stimul. 2014 Sep-Oct;7(5):740-7. doi: 10.1016/j.brs.2014.05.003. Epub 2014 Jun 4.
2
Coordinated reset neuromodulation for Parkinson's disease: proof-of-concept study.帕金森病的协调性重置神经调节：概念验证研究。
Mov Disord. 2014 Nov;29(13):1679-84. doi: 10.1002/mds.25923. Epub 2014 Jun 28.
3
Reduced variability of auditory alpha activity in chronic tinnitus.慢性耳鸣患者听觉α活动的变异性降低。
Neural Plast. 2014;2014:436146. doi: 10.1155/2014/436146. Epub 2014 May 19.
4
Amplification with hearing aids for patients with tinnitus and co-existing hearing loss.为耳鸣合并听力损失患者使用助听器进行放大。
Cochrane Database Syst Rev. 2014 Jan 31;2014(1):CD010151. doi: 10.1002/14651858.CD010151.pub2.
5
Safety and efficacy of vagus nerve stimulation paired with tones for the treatment of tinnitus: a case series.迷走神经刺激联合音调治疗耳鸣的安全性和有效性：病例系列研究
Neuromodulation. 2014 Feb;17(2):170-9. doi: 10.1111/ner.12127. Epub 2013 Nov 20.
6
The role of electroconvulsive and neuromodulation therapies in the treatment of geriatric depression.电抽搐和神经调节疗法在老年抑郁症治疗中的作用。
Psychiatr Clin North Am. 2013 Dec;36(4):607-30. doi: 10.1016/j.psc.2013.08.007. Epub 2013 Oct 6.
7
Neurostimulation in the treatment of epilepsy.神经刺激治疗癫痫。
Exp Neurol. 2013 Jun;244:87-95. doi: 10.1016/j.expneurol.2013.04.004. Epub 2013 Apr 11.
8
Neural substrates predicting improvement of tinnitus after cochlear implantation in patients with single-sided deafness.预测单侧聋患者人工耳蜗植入后耳鸣改善的神经基础。
Hear Res. 2013 May;299:1-9. doi: 10.1016/j.heares.2013.02.001. Epub 2013 Feb 13.
9
Transcutaneous vagus nerve stimulation in tinnitus: a pilot study.经皮迷走神经刺激治疗耳鸣：一项初步研究。
Acta Otolaryngol. 2013 Apr;133(4):378-82. doi: 10.3109/00016489.2012.750736. Epub 2012 Dec 13.
10
Directing neural plasticity to understand and treat tinnitus.引导神经可塑性以理解和治疗耳鸣。
Hear Res. 2013 Jan;295:58-66. doi: 10.1016/j.heares.2012.10.001. Epub 2012 Oct 23.

成人耳鸣的神经调节（去同步化）治疗

Neuromodulation (desynchronisation) for tinnitus in adults.

作者信息

Hoare Derek J, Whitham Diane, Henry James A, Shorter Gillian W

机构信息

National Institute for Health Research (NIHR) Nottingham Hearing Biomedical Research Unit, University of Nottingham, Nottingham, UK.

Nottingham Clinical Trials Unit, Queen's Medical Centre, Nottingham, UK.

出版信息

Cochrane Database Syst Rev. 2015 Jun 19. doi: 10.1002/14651858.CD011760.

DOI:10.1002/14651858.CD011760
PMID:40756134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7617981/
Abstract

UNLABELLED

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows.

MAIN OBJECTIVE

To evaluate the clinical effectiveness of neuromodulation therapies that explicitly target pathological synchronous activity to reduce tinnitus perception in order to reduce tinnitus distress.

SECONDARY OBJECTIVES

To evaluate the effectiveness of neuromodulation therapies in terms of reduced co-morbid symptoms and improved quality of life.To review the physiological changes and adverse events associated with different neuromodulation (desynchronisation) therapies.

摘要

未标注

这是一项Cochrane系统评价（干预措施）的方案。目标如下。

主要目标

评估明确针对病理性同步活动以减轻耳鸣感知从而减轻耳鸣困扰的神经调节疗法的临床效果。

次要目标

评估神经调节疗法在减轻共病症状和改善生活质量方面的效果。回顾与不同神经调节（去同步化）疗法相关的生理变化和不良事件。