Avogo Emmanuella Wesome, Burlingame Nicholas A, Badenahalli Narasimhaiah Swaroopa, Delorme-Axford Elizabeth
Biological Sciences, Oakland University, Rochester, Michigan, United States.
MicroPubl Biol. 2025 Jul 10;2025. doi: 10.17912/micropub.biology.001698. eCollection 2025.
Macroautophagy/autophagy is a conserved mechanism of cellular degradation and recycling. Autophagy is a multi-step process that must be precisely regulated at multiple levels (transcriptional, post-transcriptional, translational, and post-translational). However, there is a gap in our understanding of the molecular details of these mechanisms. Therefore, characterization of factors modulating autophagy and autophagy-related ( ) genes is an important area for investigation. Here, we used a bioinformatics approach to screen 37 yeast genes using the YEASTRACT database to identify potential regulators. Through our selection criteria, we discovered one novel factor-Mot2p. Our findings support that the yeast Mot2 protein is a regulator of cell survival, , and potentially, autophagy.
巨自噬/自噬是一种保守的细胞降解和再循环机制。自噬是一个多步骤过程，必须在多个水平（转录、转录后、翻译和翻译后）进行精确调控。然而，我们对这些机制的分子细节的理解存在差距。因此，表征调节自噬和自噬相关（ ）基因的因子是一个重要的研究领域。在这里，我们使用生物信息学方法，利用YEASTRACT数据库筛选了37个酵母基因，以鉴定潜在的调节因子。通过我们的筛选标准，我们发现了一个新因子——Mot2p。我们的研究结果支持酵母Mot2蛋白是细胞存活、 以及潜在的自噬的调节因子。
