Cordero Luis J, Smithwick Zoe, Cederlund Berit, Lom Barbara
Neuroscience Program, Davidson College, Davidson, North Carolina, United States.
Neuroscience Program; Gender and Sexuality Studies Department, Davidson College, Davidson, North Carolina, United States.
MicroPubl Biol. 2025 Jul 10;2025. doi: 10.17912/micropub.biology.001505. eCollection 2025.
This study exposed developing tadpoles to the common antidepressant fluoxetine (FLU). Behaviorally, stage 46 control (0 nM) tadpoles significantly preferred white over black backgrounds, a potential anti-predation behavior, while tadpoles reared in 0.3 or 300 nM FLU did not display this preference. Anatomically, stage 46 tadpoles reared in 300 nM FLU appeared similar to controls (0 nM) yet measured slightly and significantly larger in six of seven aspects of gross morphology measured (total length, tail length, body length, body height, eye diameter, internasal distance). Consequently, developmental FLU exposure may subtly alter specific aspects of tadpole morphology and behavior.
本研究将发育中的蝌蚪暴露于常见的抗抑郁药氟西汀（FLU）中。在行为方面，46期对照（0 nM）蝌蚪显著偏好白色背景而非黑色背景，这是一种潜在的抗捕食行为，而在0.3或300 nM氟西汀中饲养的蝌蚪则未表现出这种偏好。在解剖学上，在300 nM氟西汀中饲养的46期蝌蚪看起来与对照组（0 nM）相似，但在所测量的七个总体形态学方面中的六个方面（总长度、尾长、体长、体高、眼直径、鼻间距）略微且显著更大。因此，发育过程中暴露于氟西汀可能会微妙地改变蝌蚪形态和行为的特定方面。
