Gessaga E C, Urich H
Clin Neuropathol. 1985 Nov-Dec;4(6):238-45.
Five cases are presented with different types of cerebellar lesions which may be encountered in epileptics. Case 1 represents typical postical lesions, Case 2 perinatal anoxic-ischemic damage, Case 3 transneuronal degeneration causing crossed cerebellar atrophy, Case 4 iatrogenic cerebellar atrophy due to Phenytoin toxicity. Case 5 illustrates the interaction of two mechanisms, postictal lobular sclerosis and transneuronal degeneration. It is suggested that by attention to the type and distribution of the cerebellar lesions, to the clinical history and to the distribution of lesions in other parts of the brain the pathogenetic mechanisms can be elucidated in most cases.
本文介绍了五例癫痫患者可能出现的不同类型小脑病变。病例1为典型的发作后病变，病例2为围产期缺氧缺血性损伤，病例3为导致交叉性小脑萎缩的跨神经元变性，病例4为苯妥英毒性所致的医源性小脑萎缩。病例5说明了两种机制的相互作用，即发作后小叶硬化和跨神经元变性。建议通过关注小脑病变的类型和分布、临床病史以及大脑其他部位的病变分布，在大多数情况下可以阐明发病机制。
