Ramanna L, Waxman A D, Brachman M B, Tanasescu D E, Chapman N, Braunstein G D
Clin Nucl Med. 1985 Oct;10(10):687-9. doi: 10.1097/00003072-198510000-00003.
The authors have previously shown that the definition of ablation of thyroid tissue in patients treated with thyroidectomy and radioiodine (I-131) for thyroid carcinoma depends upon the dose of I-131 used to scan the patient. The therapeutic response to I-131 therapy was evaluated in a group of ten differentiated thyroid cancer patients who had a negative 2-mCi (-2 mCi) diagnostic study, but had a positive 10-mCi (+10 mCi) diagnostic study (group 1) during their follow-up evaluation. These results were compared to another group of ten differentiated thyroid cancer patients who received I-131 ablation therapy based on a positive 2-mCi (+2 mCi) I-131 scan (group 2). Six patients in group 1 and eight in group 2 had improvement or ablation of residual tissue based on the 10-mCi scan following therapy. The difference in response between the two groups was not statistically significant (P = 0.63) by two-tailed Fisher's exact test, indicating that even patients with -2-mCi, but +10-mCi scans may respond to I-131 therapy. Whether the large dose therapy makes any impact on the clinical outcome has not been answered by this study.
作者们之前已经表明，对于因甲状腺癌接受甲状腺切除术和放射性碘（I - 131）治疗的患者，甲状腺组织消融的定义取决于用于扫描患者的I - 131剂量。在一组十名分化型甲状腺癌患者中评估了I - 131治疗的疗效，这些患者在随访评估期间2毫居里（-2 mCi）诊断性检查结果为阴性，但10毫居里（+10 mCi）诊断性检查结果为阳性（第1组）。将这些结果与另一组十名基于2毫居里（+2 mCi）I - 131扫描阳性接受I - 131消融治疗的分化型甲状腺癌患者（第2组）进行比较。根据治疗后10毫居里扫描结果，第1组有6名患者、第2组有8名患者残留组织得到改善或消融。通过双侧费舍尔精确检验，两组之间的反应差异无统计学意义（P = 0.63），这表明即使是2毫居里扫描结果为阴性但10毫居里扫描结果为阳性的患者也可能对I - 131治疗有反应。本研究尚未回答大剂量治疗是否对临床结果有任何影响。
