Yi Taijun, Lin Zejin, Mai Ziyan, Liang Yongling, Zhong Chengrui, Li Xingyu, Wang Wandi, Huang Xiaoyue, Lin Zeyu, Wan Yunle, Li Guolin
Department of General Surgery (Hepatobiliary, Pancreatic and Splenic Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Front Endocrinol (Lausanne). 2025 Jul 18;16:1592788. doi: 10.3389/fendo.2025.1592788. eCollection 2025.
The triglyceride-glucose (TyG) index has emerged as a reliable surrogate marker for insulin resistance and is associated with multiple malignancies. However, its role in pancreatic cancer liver metastasis (PCLM) remains unclear. This study aimed to investigate the relationship between TyG index and PCLM and evaluate its predictive value for PCLM.
This study enrolled 172 patients diagnosed with pancreatic cancer at Sixth Affiliated Hospital of Sun Yat-sen University between 2021 and 2024. Both cross-sectional and longitudinal analyses were employed. Logistic regression, propensity score matching (PSM) and subgroup analysis were utilized to assess the relationship between TyG index and PCLM, and a predictive model was constructed. Kaplan-Meier curves and cox proportional hazards regression analysis were conducted to assess the impact on liver metastasis. LASSO regression and Firth regression were conducted to avoid over-fitting issue. Restricted cubic splines (RCS) were applied to explore the nonlinear relationship.
A significant inverse association was observed between TyG index level and PCLM incidence. Both multivariate logistic and cox regression suggested that a lower TyG index is associated with an increased risk of PCLM. A nomogram model was established and possessed a moderate degree of predictive accuracy (AUC = 0.75, 95% CI = 0.67-0.82). Notably, similar conclusions were reached in the subgroup of pancreatic ductal adenocarcinoma.
Comprehensive analysis suggest that higher TyG index level is associated with reduced risk for PCLM, offering significant guidance for the prediction and early intervention of PCLM.
甘油三酯-葡萄糖（TyG）指数已成为胰岛素抵抗的可靠替代标志物，并与多种恶性肿瘤相关。然而，其在胰腺癌肝转移（PCLM）中的作用仍不清楚。本研究旨在探讨TyG指数与PCLM之间的关系，并评估其对PCLM的预测价值。
本研究纳入了2021年至2024年期间在中山大学附属第六医院确诊为胰腺癌的172例患者。采用横断面和纵向分析。利用逻辑回归、倾向评分匹配（PSM）和亚组分析来评估TyG指数与PCLM之间的关系，并构建预测模型。进行Kaplan-Meier曲线和Cox比例风险回归分析以评估对肝转移的影响。进行LASSO回归和Firth回归以避免过度拟合问题。应用受限立方样条（RCS）来探索非线性关系。
观察到TyG指数水平与PCLM发生率之间存在显著的负相关。多变量逻辑回归和Cox回归均表明，较低的TyG指数与PCLM风险增加相关。建立了列线图模型，其具有中等程度的预测准确性（AUC = 0.75，95% CI = 0.67-0.82）。值得注意的是，在胰腺导管腺癌亚组中得出了类似的结论。
综合分析表明，较高的TyG指数水平与PCLM风险降低相关，为PCLM的预测和早期干预提供了重要指导。
