甘油三酯-葡萄糖指数与癌症风险的关系：一项荟萃分析。
Association between triglyceride glucose index and risk of cancer: A meta-analysis.
机构信息
Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun, China.
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China.
出版信息
Front Endocrinol (Lausanne). 2023 Jan 12;13:1098492. doi: 10.3389/fendo.2022.1098492. eCollection 2022.
BACKGROUND
Triglyceride glucose (TyG) index as a more convenient and reliable predictor of insulin resistance (IR) is thought to be associated with many diseases, but its relationship with cancer remains unclear.
METHODS
The meta-analysis was conducted to evaluate the effects of TyG index on cancer risk utilizing the available evidence. PubMed, EMBASE, Medline, Cochrane Library and Web of Science were searched from their inception up to July 2022. A random-effects model was used to calculate the effect estimates and 95% confidence intervals (CIs).
RESULTS
A total of 6 observational studies met our inclusion criteria, which including 992292 participants. The meta-analysis indicated that the higher TyG index increased cancer risk compared to the lower TyG index group (total effect size =1.14, 95% CI [1.08, 1.20], <0.001).
CONCLUSIONS
Our meta-analysis found that higher TyG index may increase the risk of cancer. More prospective cohort studies and basic research are warranted to verify the relationship.
背景
三酰甘油-葡萄糖（TyG）指数作为一种更方便、可靠的胰岛素抵抗（IR）预测指标，被认为与许多疾病相关，但它与癌症的关系尚不清楚。
方法
本荟萃分析旨在利用现有证据评估 TyG 指数对癌症风险的影响。从建库起至 2022 年 7 月，我们检索了 PubMed、EMBASE、Medline、Cochrane 图书馆和 Web of Science。采用随机效应模型计算效应估计值和 95%置信区间（CI）。
结果
共有 6 项观察性研究符合纳入标准，共纳入 992292 名参与者。荟萃分析表明，与 TyG 指数较低的组相比，TyG 指数较高与癌症风险增加相关（总效应量=1.14，95%CI [1.08, 1.20]，<0.001）。
结论
本荟萃分析发现，较高的 TyG 指数可能会增加癌症风险。需要更多的前瞻性队列研究和基础研究来验证这种关系。
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