Jiang Yuan, Wang Xiaoyan, Lei Lei, Liu Lihua, Wu Danfeng, Zhang Siqi, Tang Dairong, Fan Lingli, Wen Zhou, Xue Xiaojing, Feng Gang
Department of Oncology, Mianyang Central Hospital, Sichuan Province, China.
State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Yuzhong District, China.
SAGE Open Med. 2025 Jul 29;13:20503121251358313. doi: 10.1177/20503121251358313. eCollection 2025.
Immune checkpoint inhibitors therapy in cancer patients may induce immune-related diabetes mellitus through islet β-cell destruction, necessitating systematic glycemic management. This scoping review aims to identify and synthesize evidence on glycemic management strategies for immune-related diabetes mellitus. Guided by Arksey and O'Malley's five-stage scoping review framework, we strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist. A systematic search was conducted across guideline repositories, academic databases, and professional oncology/endocrinology association websites. The search period spanned from database inception to June 30, 2024. Of 5085 initially identified records, 9 studies met inclusion criteria. Evidence was synthesized into five key domains: (1) risk assessment and early detection, (2) therapeutic interventions and monitoring, (3) patient education, (4) glycemic target optimization, and (5) multidisciplinary care coordination. This review consolidates evidence-based best practices for immune-related diabetes mellitus management derived from rigorous methodology. Clinicians should tailor these strategies to individual patient profiles to optimize outcomes while mitigating treatment disruptions.
癌症患者的免疫检查点抑制剂疗法可能通过胰岛β细胞破坏诱发免疫相关性糖尿病，因此需要进行系统的血糖管理。本范围综述旨在识别和综合有关免疫相关性糖尿病血糖管理策略的证据。以阿克西和奥马利的五阶段范围综述框架为指导，我们严格遵循系统评价和Meta分析扩展版的范围综述清单的首选报告项目。在指南库、学术数据库以及专业肿瘤学/内分泌学协会网站上进行了系统检索。检索期从数据库建立到2024年6月30日。在最初识别的5085条记录中，9项研究符合纳入标准。证据被综合为五个关键领域：（1）风险评估和早期检测，（2）治疗干预和监测，（3）患者教育，（4）血糖目标优化，以及（5）多学科护理协调。本综述整合了通过严格方法得出的免疫相关性糖尿病管理的循证最佳实践。临床医生应根据个体患者情况调整这些策略，以优化治疗效果，同时减少治疗中断。
