Czyz Sonia, Jafarian Fatemeh, Holfeld Karen
Department of Medicine, University of Calgary, Calgary, AB, Canada.
Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
SAGE Open Med Case Rep. 2025 Jul 31;13:2050313X251358966. doi: 10.1177/2050313X251358966. eCollection 2025.
Inherited reticulate pigmentary disorders (IRPD) are a group of rare dermatologic conditions characterized by distinct reticulate patterns of hyperpigmentation and/or hypopigmentation of the skin. These conditions are considered genodermatoses caused by genetic mutations that are often inherited in affected families. IRPDs exhibit considerable phenotypic variability, ranging from having minimal or no systemic involvement to profound associations with neurocognitive, immunologic, and other organ abnormalities. Here, we discuss a rare case of dyschromatosis symmetrica hereditaria in an otherwise healthy 6-year-old boy. In this report, we aim to present the clinical manifestations of one subtype of reticulate pigmentary genodermatosis that, although uncommon in regions like Canada, immigration from other parts of the world, like Asia, highlights the need for awareness among Canadian physicians.
遗传性网状色素沉着障碍（IRPD）是一组罕见的皮肤病，其特征是皮肤出现独特的网状色素沉着和/或色素减退模式。这些疾病被认为是由基因突变引起的遗传性皮肤病，通常在受影响的家族中遗传。IRPD表现出相当大的表型变异性，从极少或没有全身受累到与神经认知、免疫和其他器官异常有密切关联。在此，我们讨论一名6岁健康男孩患对称性遗传性色素异常症的罕见病例。在本报告中，我们旨在呈现一种网状色素沉着遗传性皮肤病亚型的临床表现，尽管在加拿大等地区并不常见，但来自世界其他地区（如亚洲）的移民情况凸显了加拿大医生提高认识的必要性。
