颅内体积在不同种族和性别的归一化特性。
The normalizing properties of intracranial volume across race and sex.
作者信息
Liu Peirong, Zemlyanker Dina, Gopinath Karthik, Cheng You, He Yingnan, Izquierdo-Garcia David, Gomez-Isla Teresa, Das Sudeshna, Nasr Shahin, Sheth Kevin N, Rosen Matthew S, Kimberly W Taylor, de Havenon Adam, Shen Francis X, Iglesias Juan Eugenio
机构信息
Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Brain Commun. 2025 Jul 16;7(4):fcaf271. doi: 10.1093/braincomms/fcaf271. eCollection 2025.
In volumetric analysis of the human brain with MRI, intracranial volume is an important covariate as it has a strong correlation with the volume of regions of interest in the brain. Therefore, accurate adjustment for intracranial volume (e.g. by division) is essential to mitigate the impact of head size on brain measurements. In this study, we assess the effects of intracranial volume normalization on differences across sex and racial groups, using a diverse cohort with 5977 subjects from three different (self-reported) races. We show that (i) differences in intracranial volume across sex are consistent across race and vice versa; and (ii) intracranial volume normalization almost completely accounts for differences by race and sex. These results suggest that subjects of different sexes and races can be safely aggregated in volumetric studies by normalizing the volume of regions of interest to intracranial volume.
在通过磁共振成像（MRI）对人脑进行容积分析时，颅内体积是一个重要的协变量，因为它与大脑中感兴趣区域的体积有很强的相关性。因此，对颅内体积进行准确校正（例如通过除法）对于减轻头部大小对脑部测量的影响至关重要。在本研究中，我们使用来自三个不同（自我报告）种族的5977名受试者组成的多样化队列，评估颅内体积标准化对不同性别和种族群体差异的影响。我们发现：（i）性别间颅内体积的差异在不同种族中是一致的，反之亦然；（ii）颅内体积标准化几乎完全解释了种族和性别的差异。这些结果表明，通过将感兴趣区域的体积标准化为颅内体积，不同性别和种族的受试者可以安全地纳入容积研究。
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