Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Nat Commun. 2020 Feb 10;11(1):800. doi: 10.1038/s41467-019-14161-7.
Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between -0.11 and -0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.
如果我们要确定与年龄相关的认知能力下降相关的生物标志物，并开发治疗方法来帮助减少这种下降，那么确定与晚年认知功能相关的生物学标志物是很重要的。在这里，我们研究了洛锡安出生队列 1936 年（LBC1936，N=798）、洛锡安出生队列 1921 年（LBC1921，N=165）和 INTERVAL 生物资源（N=4451）中 90 种神经相关蛋白（Olink® Proteomics）的血浆水平与一般流体认知能力之间的关联。在 LBC1936 中，有 22 种蛋白质与一般流体认知能力显著相关（β值在-0.11 到-0.17 之间）。MRI 评估的总脑体积部分介导了这 10 种蛋白质与一般流体认知能力之间的关联。在 INTERVAL 的年龄匹配子样本中，22 种蛋白质的效应大小虽然较小，但与 LBC1936 中的方向相同。一些神经相关蛋白质的血浆水平与晚年的一般流体认知能力相关，在某些情况下，由大脑体积介导。
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