Kennedy Martin A
Carney Centre for Pharmacogenomics and Gene Structure and Function Laboratory, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
J R Soc N Z. 2024 Oct 6;55(6):2422-2439. doi: 10.1080/03036758.2024.2406824. eCollection 2025.
Pharmacogenetics is the study of genetic variants in genes which may impact on the outcome of drug treatment, either through safety considerations (occurrence of adverse drug reactions or therapeutic failure) or altered drug pharmacokinetics. This paper provides a brief history of pharmacogenetics research in the Aotearoa/New Zealand context, and a commentary on our current state. Factors that have limited translation of pharmacogenetic knowledge into ou r healthcare system are considered, and possible solutions to these are proposed. Pharmacogenetic knowledge has long been invoked as a way to improve the safety and success of drug prescribing, but (with some notable exceptions) it has largely failed to achieve this promise. Several barriers to clinical implementation need to be overcome to ensure that pharmacogenetics becomes a key component of precision health for all people in Aotearoa/New Zealand.
药物遗传学是对基因中的遗传变异进行研究，这些变异可能会通过安全性考量（药物不良反应的发生或治疗失败）或药物药代动力学改变，从而影响药物治疗的结果。本文简述了新西兰背景下药物遗传学研究的历史，并对当前状况进行了评论。文中考虑了限制药物遗传学知识转化到我们医疗体系中的因素，并提出了可能的解决办法。长期以来，药物遗传学知识一直被视为提高药物处方安全性和成功率的一种方式，但（除了一些显著的例外情况）它在很大程度上未能实现这一承诺。为确保药物遗传学成为新西兰所有人精准医疗的关键组成部分，需要克服临床应用中的几个障碍。
