McGurk M, Goepel J R, Hancock B W
Clin Radiol. 1985 Sep;36(5):455-8. doi: 10.1016/s0009-9260(85)80184-7.
One thousand and two consecutive patients with lymphoma were referred to the Regional Radiotherapy and Oncology Centre at Weston Park Hospital, Sheffield from 1970 to 1982 inclusive. Four hundred and seventy (47%) of the lymphomas occurred in the head and neck and 49 (10.4%) of these were extranodal. These 49 patients with primary extranodal lymphoma of the head and neck were reviewed with regard to clinical presentation, histological grade, treatment and survival. The specialists involved in the initial diagnosis were, in order of frequency, ear, nose and throat surgeons, general surgeons, ophthalmic surgeons and oral surgeons. Tonsillar and thyroid lymphomas occurred most frequently and constituted 71.0% of this series. All extranodal lymphomas were non-Hodgkin's lymphomas and two-thirds were graded as histologically unfavourable. Clinical staging showed that 65% of tonsillar lymphomas had local lymph node involvement at the time of diagnosis (Stage II); only 25% of lymphomas from other sites were Stage II. Radiotherapy was the primary treatment and was associated with a cumulative survival rate of 46.5%. Most recurrences were within 1 year and at distant sites. Recurrent disease had a poor prognosis with only 10% achieving lasting remission. Further analysis of cumulative survival after 6 years showed 65.7% for clinical Stage I, 40.9% for Stage II and 67.6% for histological Grade I, 29.9% for Grade II.
1970年至1982年（含）期间，1022例连续的淋巴瘤患者被转诊至谢菲尔德韦斯顿公园医院的地区放疗与肿瘤中心。其中470例（47%）淋巴瘤发生在头颈部，这些病例中有49例（10.4%）为结外淋巴瘤。对这49例原发性头颈部结外淋巴瘤患者的临床表现、组织学分级、治疗及生存情况进行了回顾性分析。参与初始诊断的专科医生按出现频率依次为耳鼻喉科医生、普通外科医生、眼科医生和口腔外科医生。扁桃体和甲状腺淋巴瘤最为常见，占本系列病例的71.0%。所有结外淋巴瘤均为非霍奇金淋巴瘤，三分之二在组织学上被判定为预后不良。临床分期显示，65%的扁桃体淋巴瘤在诊断时已有局部淋巴结受累（II期）；其他部位淋巴瘤只有25%为II期。放疗是主要治疗方法，累积生存率为46.5%。大多数复发发生在1年内且为远处复发。复发性疾病预后较差，只有10%的患者实现持久缓解。对6年后的累积生存率进一步分析显示，临床I期为65.7%，II期为40.9%；组织学I级为67.6%，II级为29.9%。
