Alkhodair Yara, Hsiung Ging-Yuek R, Tee Boon Lead, Ho Pei-Chuan, Au Yeung Phoenix, Yu Wai Haung, Peavy Guerry, Henderson Victor W, Choi Yun-Beom, Li Clara, Reyes-Dumeyer Dolly, Lee Haeok, Kukull Walter A
Division of Neurology, University of British Columbia, S151 - 2211 Wesbrook Mall, UBC Hospital, Vancouver, BC V6T 2B5 Canada.
Djavad Mowafaghian Centre of Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3 Canada.
NPJ Dement. 2025;1(1):18. doi: 10.1038/s44400-025-00015-1. Epub 2025 Jul 30.
The Asian Cohort for Alzheimer's Disease (ACAD) study is a collaborative investigation of genetic and non-genetic risk factors for AD among Asian Americans and Canadians. Harmonization of diagnostic procedures across recruiting sites will be key to the dataset's efficacy. Forty-two participants who completed the consensus process across seven ACAD recruiting sites were re-reviewed by two further impartial raters. Cohen's Kappa coefficient was used to evaluate inter-rater agreement. The findings reveal the highest level of observed agreement at 88% and a Cohen's Kappa of 0.835, among site consensus participants and two levels of external review, affirming the reliability of our protocol. ACAD has developed a data collection and diagnostic process that allows consistency among sites that serve Asians speaking Korean, Chinese, and Vietnamese languages.
亚洲阿尔茨海默病队列（ACAD）研究是一项针对亚裔美国人和加拿大人中阿尔茨海默病（AD）的遗传和非遗传风险因素的合作调查。各招募地点诊断程序的统一对于数据集的有效性至关重要。在七个ACAD招募地点完成共识程序的42名参与者由另外两名公正的评估者进行了再次审查。采用科恩kappa系数来评估评估者间的一致性。研究结果显示，在地点共识参与者和两级外部审查中，观察到的一致性最高达到88%，科恩kappa系数为0.835，证实了我们方案的可靠性。ACAD已经开发出一种数据收集和诊断流程，可确保为说韩语、中文和越南语的亚洲人服务的各地点之间保持一致性。
