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行走性肺炎——并非总是如此温和。一例暴发性支原体肺炎导致严重急性呼吸窘迫综合征的病例。

Walking Pneumonia - Not Always so Timid. A Case of Severe ARDS Due to Fulminant Mycoplasma Pneumonia.

作者信息

Shyam Tharun, Noor Momna, Tun Yan N, Nanda Saumya, Khan Omair, Patti Ravi K

机构信息

Maimonides Medical Center, United States.

University of Nebraska Medical Center, United States.

出版信息

J Community Hosp Intern Med Perspect. 2025 Jul 3;15(4):88-91. doi: 10.55729/2000-9666.1498. eCollection 2025.

DOI:10.55729/2000-9666.1498
PMID:40757217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12315890/
Abstract

pneumonia (MPP) most commonly presents as bronchitis or as a self-limited 'walking' community acquired pneumonia. A fulminant form of MPP may occur in 0.5 %-2 % of patients and is characterized by rapidly progressive respiratory failure and Acute respiratory distress syndrome (ARDS). Our case highlights the importance of considering fulminant MPP as a cause of ARDS, especially in the young adult and middle-aged population. We review the current literature and management principles of this rare disease with an emphasis on antibiotic stewardship and corticosteroid therapy. Further research is needed to better understand patterns of antibiotic resistance and to establish management guidelines for fulminant MPP.

摘要

支原体肺炎(MPP)最常表现为支气管炎或自限性“轻症”社区获得性肺炎。暴发性MPP可能发生在0.5%-2%的患者中,其特征为迅速进展的呼吸衰竭和急性呼吸窘迫综合征(ARDS)。我们的病例强调了将暴发性MPP视为ARDS病因的重要性,尤其是在青壮年和中年人群中。我们回顾了这种罕见疾病的当前文献和管理原则,重点是抗生素管理和皮质类固醇治疗。需要进一步研究以更好地了解抗生素耐药模式,并建立暴发性MPP的管理指南。

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本文引用的文献

1
Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials.糖皮质激素对社区获得性肺炎病死率和临床治愈率的影响:一项随机对照试验的系统评价、荟萃分析和荟萃回归。
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Global Trends in the Proportion of Macrolide-Resistant Mycoplasma pneumoniae Infections: A Systematic Review and Meta-analysis.全球大环内酯类耐药肺炎支原体感染比例的趋势:系统评价和荟萃分析。
JAMA Netw Open. 2022 Jul 1;5(7):e2220949. doi: 10.1001/jamanetworkopen.2022.20949.
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Acute Hypoxic Respiratory Failure and Septic Shock Secondary to Mycoplasma Pneumoniae Pneumonia Complicated by Heroin Overdose.
继发于肺炎支原体肺炎合并海洛因过量的急性低氧性呼吸衰竭和感染性休克
Cureus. 2020 Oct 22;12(10):e11093. doi: 10.7759/cureus.11093.
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Tigecycline in the treatment of fulminant Mycoplasma pneumoniae pneumonia non-responsive to azithromycin and fluoroquinolone: A case report.替加环素治疗对阿奇霉素和氟喹诺酮耐药的暴发性肺炎支原体肺炎:一例报告
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Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST.
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Clinical Features of Severe or Fatal Mycoplasma pneumoniae Pneumonia.重症或致死性肺炎支原体肺炎的临床特征
Front Microbiol. 2016 Jun 1;7:800. doi: 10.3389/fmicb.2016.00800. eCollection 2016.
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Setting a standard for the initiation of steroid therapy in refractory or severe Mycoplasma pneumoniae pneumonia in adolescents and adults.为青少年及成人难治性或重症支原体肺炎的类固醇治疗起始设定标准。
J Infect Chemother. 2015 Mar;21(3):153-60. doi: 10.1016/j.jiac.2014.10.008. Epub 2014 Dec 19.
8
Clinical features, risk factors and treatment of fulminant Mycoplasma pneumoniae pneumonia: a review of the Japanese literature.猛发性肺炎支原体肺炎的临床特征、危险因素和治疗:日本文献综述。
J Infect Chemother. 2014 Mar;20(3):181-5. doi: 10.1016/j.jiac.2013.09.009. Epub 2013 Dec 11.
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J Med Microbiol. 2007 Dec;56(Pt 12):1625-1629. doi: 10.1099/jmm.0.47119-0.
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Fulminant Mycoplasma pneumoniae pneumonia.暴发性肺炎支原体肺炎
West J Med. 1995 Feb;162(2):133-42.