Harris Dillon R, Chapman-Lopez Tomas, Machek Steven B, Forsse Jeffery S, Sulak Tracey, Funderburk Leslee K
Department of Health, Human Performance, and Recreation, Robbins College of Health and Human Sciences, Baylor University, Waco, TX 76706, USA.
Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77845, USA.
Muscles. 2024 Oct 23;3(4):364-375. doi: 10.3390/muscles3040031.
Turkesterone is a naturally occurring plant steroid touted for its medicinal, pharmacological, and biological properties with no reported adverse side effects compared with traditional anabolic androgenic steroids (AAS). However, this ostensible enhancement to increase muscle protein synthesis and facilitate augmented thermogenesis remains undescribed despite uninformed and potentially haphazard consumption. To investigate whether turkesterone enhances insulin-like growth factor-1 (IGF-1) and resting metabolic rate (RMR), eleven apparently healthy males (23.3 ± 2.2) volunteered to participate in the present study with samples collected pre-, 3H post-, and 24H post-ingestion. Subsequent analyses failed to reveal any significant main condition, time, or interaction main effects for serum IGF-1, RMR, lipid, and carbohydrate metabolism ( > 0.05). However, non-significant serum IGF-1 concentrations increased with both turkesterone conditions and remained elevated when compared with placebo. Similarly, RMR remained elevated above baseline across the 3 h assessed. Although these data fail to fully support turkesterone as a potent anabolic supplement, nevertheless, our findings are foundational to persistently tease apart this supplement's purported ergogenic effects and underscore its favorable hemodynamic and gastrointestinal tolerability profile. Future investigations should, therein, aim to assess turkesterone-mediated IGF-1 increases on long-term whole-muscle growth across several training sessions to further substantiate its efficacy on anabolism.
土克甾酮是一种天然存在的植物类固醇，因其药用、药理和生物学特性而备受推崇，与传统的合成代谢雄激素类固醇（AAS）相比，未见有不良副作用的报道。然而，尽管存在不知情且可能随意服用的情况，但这种据称能增加肌肉蛋白质合成并促进产热增加的表面增强作用仍未得到描述。为了研究土克甾酮是否能提高胰岛素样生长因子-1（IGF-1）和静息代谢率（RMR），11名明显健康的男性（23.3±2.2）自愿参与本研究，在摄入前、摄入后3小时和24小时采集样本。随后的分析未能揭示血清IGF-1、RMR、脂质和碳水化合物代谢的任何显著主要条件、时间或交互主要效应（P>0.05）。然而，在两种土克甾酮条件下，血清IGF-1浓度均有非显著性增加，与安慰剂相比仍保持升高。同样，在评估的3小时内，RMR一直高于基线水平。尽管这些数据未能充分支持土克甾酮作为一种有效的合成代谢补充剂，但我们的研究结果为持续剖析这种补充剂所谓的促力效应奠定了基础，并强调了其良好的血液动力学和胃肠道耐受性。因此，未来的研究应旨在评估土克甾酮介导的IGF-1增加对多个训练阶段长期全肌肉生长的影响，以进一步证实其在合成代谢方面的功效。
