[Influence of TRH on the depressive syndrome (author's transl)].

In two cases of chronic endogenous depression changes of mood and drive have been investigated over a period of 26 days by self rating scales "ESTA". After a single dose of 250 microgramm TRH a small antidepressive effect and a clear shift of the syndrome in the direction of a mixed state could be demonstrated thus suggesting an increased desintegration of the mood-drive-system.