[The influence of thyrotrophin-releasing hormone (TRH) on depression in the alcohol withdrawal syndrome (author's transl)].

A single injection of thyrotrophin-releasing hormone (TRH) was compared to injection of nicotinic acid or saline in alcohol withdrawal syndrome. An antidepressant action of TRH was demonstrated on injection day. Thereafter there were no reliable differences between treatment groups, perhaps due to rapid spontaneous remission in all groups. Two of five patients who received TRH showed a grossly subnormal TSH response.