Horowitz G P, Whitney G, Smith J C, Stephan F K
Psychopharmacology (Berl). 1977 Apr 29;52(2):119-22. doi: 10.1007/BF00439097.
C57BL/6J mice will drink large amounts of, and display a highly positive preference for, morphine sulfate when it is dissolved in an aqueous solution of sodium saccharin. In identical test situations DBA/2J mice will drink very little of, and display a strong avoidance toward, the morphine-saccharin solution. This clear separation between morphine-accepting and morphine-rejecting animals within a single species combined with a quick and simple method of inducing high levels of morphine ingestion could facilitate the discovery of causal factors in opiate addiction.
当硫酸吗啡溶解在糖精钠水溶液中时，C57BL/6J小鼠会大量饮用，并对其表现出高度的积极偏好。在相同的测试条件下，DBA/2J小鼠则很少饮用吗啡 - 糖精溶液，并对其表现出强烈的回避。同一物种内接受吗啡和拒斥吗啡的动物之间的这种明显区分，再加上一种诱导高水平吗啡摄入的快速简单方法，可能有助于发现阿片类成瘾的因果因素。
