Oh Julia, Voigt Anita Y
Department of Dermatology, Duke University, Durham, NC, USA.
Department of Integrative Immunobiology, Duke University, Durham, NC, USA.
Nat Rev Microbiol. 2025 Aug 4. doi: 10.1038/s41579-025-01211-9.
The skin microbiome is composed of a diverse community of microorganisms, including bacteria, fungi, viruses and mites. These microorganisms have a crucial role in maintaining skin health, protecting against pathogens and modulating immune responses. In recent years, our understanding of the skin microbiome has expanded substantially with the deployment of metagenomic sequencing. This technology, by reconstructing microbial species, strains and gene pathways in the microbiomes of different cohorts, has led to identification of numerous therapeutic targets and thus propelled the development of therapeutic approaches that are aimed at leveraging these microorganisms to treat skin conditions and to improve skin health. In this Review, we discuss the composition, ecology, functions and therapeutic horizons of the human skin microbiome, presenting examples of studies that highlight potential therapeutic targets in the skin microbiome, ongoing progress in the development of skin microbiome-based therapeutics and challenges.
皮肤微生物群由多种微生物群落组成，包括细菌、真菌、病毒和螨虫。这些微生物在维持皮肤健康、抵御病原体和调节免疫反应方面发挥着关键作用。近年来，随着宏基因组测序技术的应用，我们对皮肤微生物群的认识有了显著扩展。通过重建不同队列微生物群中的微生物物种、菌株和基因途径，这项技术已鉴定出众多治疗靶点，从而推动了旨在利用这些微生物治疗皮肤疾病和改善皮肤健康的治疗方法的发展。在本综述中，我们讨论了人类皮肤微生物群的组成、生态、功能和治疗前景，列举了突出皮肤微生物群潜在治疗靶点的研究实例、基于皮肤微生物群的治疗方法的发展现状以及面临的挑战。
