Atrens D M, Ungerstedt U, Ljungberg T
Psychopharmacology (Berl). 1977 Apr 29;52(2):177-80. doi: 10.1007/BF00439106.
The effects of two new phthalane-derived bicyclic thymoleptics on hypothalamic self-stimulation were investigated in rats. The drugs, LU 10-171 and LU 5-003 are potent and highly selective reuptake blockers of 5-hydroxytryptamine (5-HT) and noradrenaline (NA), respectively. The use of a two-way shuttle-box permitted the differentiation of specific reward modulation effects from the variety of non-specific performance changes that these drugs may produce. Selective reuptake blockade of either 5HT or NA produced a dose-dependent reduction in reward that could be clearly dissociated from any non-specific performance decrements. Besides providing direct evidence for a significant role for 5HT in the mediation of hypothalamic self-stimulation, these data show that symphy increasing transmitter availability is not a sufficient condition to enhance self-stimulation reward. It is suggested that self-stimulation is dependent on response-contingent transmitter release and that any operation that increases reward-transmitter availability in a response-independent manner should attenuate self-stimulation.
在大鼠中研究了两种新的邻苯二甲烷衍生的双环抗抑郁药对下丘脑自我刺激的影响。这两种药物，LU 10 - 171和LU 5 - 003分别是强效且高度选择性的5 - 羟色胺（5 - HT）和去甲肾上腺素（NA）再摄取阻滞剂。使用双向穿梭箱可以区分这些药物可能产生的各种非特异性行为变化中的特定奖赏调节效应。对5 - HT或NA的选择性再摄取阻断会导致奖赏呈剂量依赖性降低，这可以与任何非特异性行为下降明显区分开来。这些数据除了为5 - HT在下丘脑自我刺激介导中起重要作用提供直接证据外，还表明单纯增加递质可用性并非增强自我刺激奖赏的充分条件。有人提出，自我刺激依赖于反应相关的递质释放，并且任何以反应无关方式增加奖赏递质可用性的操作都应减弱自我刺激。
