Atrens D M, Becker F T, Hunt G E
Psychopharmacology (Berl). 1980;71(1):97-9. doi: 10.1007/BF00433261.
The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situation, the present study investigated the effects of apomorphine on locomotor initiation of and escape from lateral hypothalamic stimulation in a shuttle-box. Apomorphine had relatively little effect on the initiation behavior, but it produced a large and dose-dependent inhibition of escape. These data suggest that apomorphine acts to inhibit the aversive component of lateral hypothalamic stimulation. The implications of these findings for the usefulness of the shuttle-box in investigating the pharmacology of self-stimulation are discussed.
多巴胺激动剂对自我刺激的影响存在相当大的争议。据报道，阿扑吗啡对杠杆按压式自我刺激的作用各不相同，有抑制作用、无作用或促进作用。为了研究这些差异是否可能反映杠杆按压测试情境的特殊性，本研究调查了阿扑吗啡对穿梭箱中下丘脑外侧刺激引发的运动及逃避该刺激的影响。阿扑吗啡对起始行为的影响相对较小，但对逃避行为产生了强烈且剂量依赖性的抑制作用。这些数据表明，阿扑吗啡的作用是抑制下丘脑外侧刺激的厌恶成分。本文讨论了这些发现对穿梭箱在自我刺激药理学研究中的实用性的影响。
