McLachlan R S, Nicholson R L, Black S, Carr T, Blume W T
Epilepsia. 1985 Nov-Dec;26(6):555-62. doi: 10.1111/j.1528-1157.1985.tb05691.x.
Nuclear magnetic resonance is a noninvasive technique of imaging the brain using signals produced by magnetic fields and radiowaves. Sixteen patients with refractory temporal lobe epilepsy (TLE) had magnetic resonance imaging (MRI) during investigation for possible surgical management. These images plus those of 10 normal controls, were interpreted blind and the results from the TLE patients compared to the EEG and computerized tomographic (CT) scan findings. Fourteen patients compared with one normal control had one or more of the following: small temporal lobe, small mesial temporal structures, small hemisphere, and focal mesial temporal prolonged spin-spin relaxation time. These findings correlated with the electrographically determined seizure focus in 11 patients. Enlarged or asymmetrical temporal horns were seen with equal frequency in patients and controls and did not correlate with the seizure focus. CT scans were less likely to show these changes than MRI. Correlation of the MRI changes with histopathology of resected temporal lobes was poor. MRI reveals structural and possibly functional alterations which may aid in the localization of the seizure focus in the temporal lobes of patients with refractory complex partial seizures.
核磁共振是一种利用磁场和无线电波产生的信号对大脑进行成像的非侵入性技术。16例难治性颞叶癫痫（TLE）患者在接受可能的手术治疗检查期间进行了磁共振成像（MRI）。这些图像以及10名正常对照者的图像由不知情的人员解读，并将TLE患者的结果与脑电图和计算机断层扫描（CT）结果进行比较。14例患者与1名正常对照者相比，有以下一种或多种情况：颞叶小、内侧颞叶结构小、半球小以及局灶性内侧颞叶自旋-自旋弛豫时间延长。这些发现与11例患者经脑电图确定的癫痫病灶相关。患者和对照者中出现扩大或不对称颞角的频率相同，且与癫痫病灶无关。CT扫描比MRI更不容易显示这些变化。MRI变化与切除的颞叶组织病理学之间的相关性较差。MRI揭示了结构上以及可能功能上的改变，这可能有助于定位难治性复杂部分性癫痫患者颞叶中的癫痫病灶。
