Otsubo H, Hwang P A, Hoffman H J, Becker L E, Gilday D L, Chuang S H, Harwood-Nash D
Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada.
Childs Nerv Syst. 1995 May;11(5):281-7. doi: 10.1007/BF00301761.
Twenty-eight children with intractable seizures who subsequently underwent a temporal lobectomy were studied by electroencephalogram (EEG), prolonged video EEG telemetry, computed tomography (CT), magnetic resonance imaging (MRI), and single photon emission computed tomography (SPECT) for the localization of epileptogenic foci. MRI showed abnormalities indicating epileptogenic foci in 21/25 patients and a increased signal intensity in 7/11 patients with mesial temporal sclerosis (MTS). SPECT showed corresponding abnormalities in 17/22 patients, including an interictal decrease in regional cerebral blood flow corresponding to the epileptogenic zone in 15. CT showed localized abnormalities in 16/28. All 12 patients with benign, slow-growing neoplasms showed an abnormality on CT scan. In children, MRI is essential in localizing epileptogenic abnormalities, especially MTS and cortical dysplasia. SPECT contributes to the localization of epileptogenic foci, which are often coincident with EEG abnormalities, particularly in single pathology. CT depicts benign neoplasms with calcification in the temporal lobe, which are likely to provoke complex partial seizures.
对28例难治性癫痫患儿进行了研究，这些患儿随后接受了颞叶切除术，并通过脑电图（EEG）、长时间视频脑电图遥测、计算机断层扫描（CT）、磁共振成像（MRI）和单光子发射计算机断层扫描（SPECT）来定位致痫灶。MRI显示21/25例患者有提示致痫灶的异常，7/11例内侧颞叶硬化（MTS）患者信号强度增加。SPECT显示17/22例患者有相应异常，其中15例在发作间期区域脑血流减少，对应致痫区。CT显示16/28例有局部异常。所有12例患有良性、生长缓慢肿瘤的患者CT扫描均显示异常。在儿童中，MRI对于定位致痫性异常至关重要，尤其是MTS和皮质发育异常。SPECT有助于致痫灶的定位，致痫灶常与EEG异常相符，尤其是在单一病变中。CT可显示颞叶有钙化的良性肿瘤，这些肿瘤可能引发复杂部分性发作。
